Retinal remodeling in the Tg P347L rabbit, a large-eye model of retinal degeneration

A oblique section through the bipolar cell layer and partial outer plexiform layer (upper left) of a TgP347L rabbit retina early in the degenerative process visualized with sQE :: rgb mapping. At 12–16 weeks, the TgP347L rabbit retina still has photoreceptors, but Müller cell signatures in yellow/or...

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Bibliographic Details
Published in:Journal of comparative neurology (1911) 2011-10, Vol.519 (14), p.Spc1-Spc1
Main Authors: Jones, Bryan William, Kondo, Mineo, Terasaki, Hiroko, Watt, Carl Brock, Rapp, Kevin, Anderson, James, Lin, Yanhua, Shaw, Marguerite Victoria, Yang, Jia-Hui, Marc, Robert Edward
Format: Article
Language:English
Subjects:
Bipolar cells
computational molecular phenotyping
confocal microscopy
electron microscopy
electroretinogram
Glutamic acid
human
Hypertrophy
light microscopy
Mapping
neural remodeling
Photoreceptors
rabbit
Retina
retinal degeneration
retinal remodeling
retinitis pigmentosa
transgenic
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Description
Summary:A oblique section through the bipolar cell layer and partial outer plexiform layer (upper left) of a TgP347L rabbit retina early in the degenerative process visualized with sQE :: rgb mapping. At 12–16 weeks, the TgP347L rabbit retina still has photoreceptors, but Müller cell signatures in yellow/orange can be seen indicating early altered metabolic profiles prior to glial hypertrophy. Bipolar cells are functionally switching their phenotypes at this stage as revealed by glutamate channel expression changes and AGB permeation of activated iGluRs, but appear retain their formal small molecular phenotype at this stage. The Journal of Comparative Neurology, Volume 519, Number 14, pages 2713–2733. J. Comp. Neurol., 2011. © 2011 Wiley‐Liss, Inc.
ISSN:0021-9967
1096-9861
1096-9861
DOI:10.1002/cne.22737