Structure-property investigations with dielectric study on phosphorylcholine-based polyurethane

Polyurethane with zwitterionic phosphorylcholine on the main chain was synthesized and the structures were defined with FTIR and 1HNMR. The mechanical (tensile strength, elastic modulus) and biological (platelet adhesion) evaluations of its blend films with polyurethane were of satisfactory results,...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part A 2012-07, Vol.100A (7), p.1868-1876
Main Authors: Zhang, Qi, Zhu, Dan, Su, Fu, Xie, Yun, Ma, Zhenmao, Shen, Jian
Format: Article
Language:English
Subjects:
anticoagulation
Biocompatible Materials
Biological and medical sciences
biomaterials
dielectric spectroscopy
interface
Magnetic Resonance Spectroscopy
Medical sciences
Microscopy, Electron, Scanning
Phosphorylcholine - chemistry
Polyurethanes - chemistry
Spectroscopy, Fourier Transform Infrared
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Tensile Strength
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Summary:Polyurethane with zwitterionic phosphorylcholine on the main chain was synthesized and the structures were defined with FTIR and 1HNMR. The mechanical (tensile strength, elastic modulus) and biological (platelet adhesion) evaluations of its blend films with polyurethane were of satisfactory results, which were in accordance with the requirements of the medical devices, showing their potential applications as anticoagulant biomaterials. The dielectric spectroscopy was recorded with solid films and with films in water. The dielectric dispersion of the solid films demonstrated the existence of condensed ionic structures, which lead to the rigidity enhancement of the soft segment of the phosphorylcholine‐based polyurethane, so that its elastic modulus increased. The dielectric measurement with films in water, providing a measurement for the surface properties in the aqueous environment, offered a semiquantitative description of the interface dynamics of the material with a double‐layer model, based on which a new hypothesis on the mechanism of blood or bio‐compatibility was proposed that the hydrated surface of the satisfactory biomaterials can response to the outside electromagnetic stimuli with slight strength and prompt relaxation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.34154