HLA class I polymorphisms in Tunisian patients with otosclerosis

Background: Otosclerosis is a common form of hearing impairment among Western-Eurasian adults. The cause of otosclerosis remains unknown. Autoimmune reaction against the otic capsule has been suggested as a possible aetiologic factor in otosclerosis.Aim: The present study is the first report to eval...

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Bibliographic Details
Published in:Annals of human biology 2012-05, Vol.39 (3), p.190-194
Main Authors: Bel Hadj Ali, Insaf, Ben Saida, Asma, Beltaief, Najeh, Namouchi, Imen, Besbes, Ghazi, Ghazoueni, Ezzeddine, Ben Arab, Saida
Format: Article
Language:English
Subjects:
Adolescent
Adult
Association study
Case-Control Studies
Ethnic Groups - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease
genetic susceptibility
hearing loss
histocompatibility antigens
Histocompatibility Antigens Class I - genetics
HLA-A Antigens - genetics
HLA-B Antigens - genetics
HLA-C Antigens - genetics
Humans
Male
Middle Aged
Otosclerosis - genetics
Otosclerosis - immunology
Polymorphism, Genetic
Tunisia - ethnology
Young Adult
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Summary:Background: Otosclerosis is a common form of hearing impairment among Western-Eurasian adults. The cause of otosclerosis remains unknown. Autoimmune reaction against the otic capsule has been suggested as a possible aetiologic factor in otosclerosis.Aim: The present study is the first report to evaluate the relationship between class I major histocompatibility complex (MHC) genes (HLA-A, HLA-B and HLA-Cw) and genetic susceptibility to otosclerosis in Tunisian patients.Subjects and methods: Fifty unrelated Tunisian patients exhibiting clinical otosclerosis were typed for HLA-A, HLA-B and HLA-Cw antigens and compared with 100 ethnically-matched healthy controls.Results: Increased frequencies of HLA-A*03 (OR = 4.16, Pc < 0.043), HLA-B*35 (OR = 2.76, Pc < 0.043) and HLA-Cw*03 (OR = 4.57, Pc < 0.043) antigens were found in the patients with otosclerosis compared with healthy controls. Individuals with HLA-A*30 (OR = 0.25, Pc < 0.043), HLA-B*51 (OR = 0.11, Pc < 0.043), HLA-Cw*16 (OR = 0.08, Pc < 0.043) and Cw*06 (OR = 0.32, Pc < 0.043) antigens have a protective effect against otosclerosis.Conclusions: In conclusion, the data suggest that a variation in class I HLA antigens could be a genetic factor involved in susceptibility to otosclerosis in the Tunisian population.
ISSN:0301-4460
1464-5033
DOI:10.3109/03014460.2012.671849