Induction of Protective Immunity Against Cryptococcosis

Cryptococcus neoformans , the predominant etiological agent of cryptococcosis, is an encapsulated fungal pathogen that can cause life-threatening infections of the central nervous system in immune compromised individuals resulting in high morbidity and mortality. Consequently, several studies have e...

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Bibliographic Details
Published in:Mycopathologia (1975) 2012-06, Vol.173 (5-6), p.387-394
Main Authors: Wozniak, Karen L., Hardison, Sarah, Olszewski, Michal, Wormley, Floyd L.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Central nervous system
Conferences
Congresses as Topic
Cryptococcal infections
Cryptococcosis
Cryptococcosis - immunology
Cryptococcosis - microbiology
Cryptococcus neoformans
Cryptococcus neoformans - immunology
Cytokines
Development and progression
Disease
Diseases
Eukaryotic Microbiology
Genotype & phenotype
Health aspects
Host-Pathogen Interactions
Humans
Immune response
Immunity
Infection
Infections
International conferences
Life Sciences
Lungs
Medical Microbiology
Microbial Ecology
Microbiology
Morbidity
Mortality
Nervous system
Nitric oxide
Pathogens
Pathology
Plant Sciences
Vaccines
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Summary:Cryptococcus neoformans , the predominant etiological agent of cryptococcosis, is an encapsulated fungal pathogen that can cause life-threatening infections of the central nervous system in immune compromised individuals resulting in high morbidity and mortality. Consequently, several studies have endeavored to understand those mechanisms that mediate resistance and susceptibility to Cryptococcus infection. In this review, we will examine the contributions of various components of the innate and adaptive immune response toward protection against cryptococcosis. We will focus our discussion on studies presented at the 8th International Conference on Cryptococcus and Cryptococcosis (ICCC). Remarkable progress has been made toward our understanding of host immunity and susceptibility to cryptococcal infection and the potential for vaccine development.
ISSN:0301-486X
1573-0832
DOI:10.1007/s11046-011-9505-8