Antifungal susceptibility of Candida albicans in biofilms

Summary Candida albicans are the most common fungi associated with biofilm‐related infections. Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric substances. The most important feature of biofilm growth is the high resistance to antimicrobial agents that can...

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Bibliographic Details
Published in:Mycoses 2012-05, Vol.55 (3), p.199-204
Main Authors: Tobudic, Selma, Kratzer, Christina, Lassnigg, Andrea, Presterl, Elisabeth
Format: Article
Language:eng ; ger
Subjects:
Animals
Antifungal Agents - pharmacology
antifungal resistance
Biofilm
Biofilms - drug effects
C. albicans
Candida albicans
Candida albicans - drug effects
Candida albicans - physiology
Candidiasis - drug therapy
Candidiasis - microbiology
Humans
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Summary:Summary Candida albicans are the most common fungi associated with biofilm‐related infections. Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric substances. The most important feature of biofilm growth is the high resistance to antimicrobial agents that can be up to 1000‐fold greater than that of planktonic cells. This review discusses the factors affecting antifungal resistance as well as activity of mono‐ and combination therapy of different antifungal classes and antifungal activity in vitro and in vivo against C. albicans biofilms.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2011.02076.x