Parenthood in pediatric liver transplant patients

Ecevit Ç, Ünal F, Baran M, Aydoğdu S. Parenthood in pediatric liver transplant patients. :  Liver transplantation has become a universally accepted treatment for numerous congenital and acquired hepatic disorders that cause liver failure. Without liver transplantation, patients in their reproductive...

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Bibliographic Details
Published in:Pediatric transplantation 2012-06, Vol.16 (4), p.346-349
Main Authors: Ecevit, Çiğdem, Ünal, Fatih, Baran, Maşallah, Aydoğdu, Sema
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Female
Fertility
General aspects
Humans
Hypercalcemia - etiology
Infant
Live Birth
Liver Transplantation
Liver, biliary tract, pancreas, portal circulation, spleen
Male
Medical sciences
parenthood
Postoperative Complications
Pregnancy
Pregnancy Complications - etiology
Premature Birth - etiology
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the digestive system
Young Adult
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Summary:Ecevit Ç, Ünal F, Baran M, Aydoğdu S. Parenthood in pediatric liver transplant patients. :  Liver transplantation has become a universally accepted treatment for numerous congenital and acquired hepatic disorders that cause liver failure. Without liver transplantation, patients in their reproductive years are afflicted with oligospermia or azoospermia in men and amenorrhea in women, with infertility being a consequence in both sexes. The aim of this study is to describe our experiences concerning the parenthood of pediatric individuals who are successful recipients of liver transplantations coming into the reproductive years of life. We retrospectively analyzed data of 207 pediatric liver transplanted patients (96 women, 111 men). Among them, three women conceived and delivered four babies, and two men admitted to paternity of two children after they all had been recipients of liver transplants. All female transplant recipients had received tacrolimus‐based immunosuppression. Preterm delivery was the most clinically important complication among these patients. Only one of the female patients experienced hypercalcemia during the pregnancy. None had any other complications such as hypertension, preeclampsia, cholestasis, or diabetes. There was no graft insufficiency, rejection, or birth defect. We concluded that maternity and paternity in liver transplant patients show normal outcomes even though this procedure occurs in childhood, and pregnancy did not seem to impair graft function in patients receiving immunosuppressive drugs.
ISSN:1397-3142
1399-3046
DOI:10.1111/j.1399-3046.2012.01671.x