Hypertensive leg ulcers: epidemiological characteristics and prognostic factors for healing in a prospective cohort

The data concerning changes in the characteristics of hypertensive leg ulcers (HLU) were taken from open studies in a small patient cohort. The aim of this study was to describe the epidemiological characteristics and to identify prognostic factors for healing in a prospective cohort of 59 patients...

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Bibliographic Details
Published in:Annales de dermatologie et de vénéréologie 2012-05, Vol.139 (5), p.346-349
Main Authors: Senet, P, Beneton, N, Debure, C, Modiano, P, Lok, C, Bedane, C, Truchetet, F, Fays-Bouchon, S, Vicaut, E, Chosidow, O
Format: Article
Language:fre
Subjects:
Aged
Angiogenesis Inducing Agents - therapeutic use
Cicatrix
Double-Blind Method
Female
Humans
Hypertension - complications
Leg Ulcer - diagnosis
Leg Ulcer - drug therapy
Leg Ulcer - epidemiology
Leg Ulcer - etiology
Male
Prognosis
Prospective Studies
Proto-Oncogene Proteins c-sis - therapeutic use
Remission Induction
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Summary:The data concerning changes in the characteristics of hypertensive leg ulcers (HLU) were taken from open studies in a small patient cohort. The aim of this study was to describe the epidemiological characteristics and to identify prognostic factors for healing in a prospective cohort of 59 patients presenting HLU. The cohort comprised patients included in a randomized, double-blind, controlled study published elsewhere; the patients were receiving becaplermin gel (Regranex(®)) or Duoderm Hydrogel™ once daily for eight weeks for the most recent wound. Total follow-up was 12 weeks. The epidemiological analysis was performed for 59 consecutive patients randomized in 17 dermatology departments. Mean patient age was 74.5 ± 9 years and 61% were female. Mean wound duration was 11.1 ± 9 weeks and median wound area was 16 cm(2) (q1; q3: 8; 25.5). Among, 94.9% of patients had hypertension and 39.7% were diabetic. A homolateral peripheral pulse was present in 91.5% of patients. At the end of follow-up, complete wound healing was obtained in 30.5% of the patients. In univariate analysis, neither the foregoing criteria nor the treatment group were significantly associated with healing during the study. This study confirms female predominance, old age, prevalence of diabetes and delay in the diagnosis of HLU. The prognosis for healing does not appear to be dependent on wound duration, wound area or the presence of moderate peripheral arterial disease, doubtless because this condition progresses by episodes of flare-up and under specific conditions.
ISSN:0151-9638
DOI:10.1016/j.annder.2011.09.191