Accurate fat fraction quantification by multiecho gradient-recalled-echo magnetic resonance at 1.5T in rats with nonalcoholic fatty liver disease

To assess the diagnostic accuracy of a new reconstruction technique for gradient-recalled-echo magnetic resonance (MR) sequences that provides a full decomposition of the water and fat content inside a voxel for nonalcoholic fatty liver disease (NAFLD) in rats. Rats were randomized into two groups....

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Published in:European journal of radiology 2012-06, Vol.81 (6), p.1122-1127
Main Authors: Hijona, Elizabeth, Sánchez-González, Javier, Alústiza, Jose M., Hijona, Lander, Arenas, Juan, García, Elisabeth, Rojas, Nohelia, Portillo, Maria P., Jiménez, Raúl, Aldazabal, Pablo, Bujanda, Luis
Format: Article
Language:English
Subjects:
Adipose Tissue - pathology
Animals
Biochemical
Fat
Fatty liver
Fatty Liver - pathology
Image Processing, Computer-Assisted - methods
Magnetic resonance
Magnetic Resonance Imaging - methods
Male
multi-echo
Non-alcoholic Fatty Liver Disease
Prospective Studies
Random Allocation
Rats
Rats, Wistar
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Summary:To assess the diagnostic accuracy of a new reconstruction technique for gradient-recalled-echo magnetic resonance (MR) sequences that provides a full decomposition of the water and fat content inside a voxel for nonalcoholic fatty liver disease (NAFLD) in rats. Rats were randomized into two groups. A control group (n=10) was given free access to regular dry rat chow for 4 weeks. The steatosis (n=40) group was given free access to feed and water 4 days per week, and fasted for the remaining 3 days for 4 weeks. All rats were killed at 4 weeks and assessed for fatty infiltration and biochemical method. The average fat content using the gold standard method was 2.65g (2.20–3.05) of fat/100g liver for the control group and 4.14g (1.95–8.60) of fat/100g of liver for the overfed group (p
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2011.02.065