Effects of depot growth hormone replacement on thyroid function and volume in adults with congenital isolated growth hormone deficiency

Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2012-03, Vol.35 (3), p.265-268
Main Authors: Leite, N. T. F., Salvatori, R., Alcântara, M. R. S., Alcântara, P. R. S., Oliveira, C. R. P., Oliveira, J. L. M., Anjos-Andrade, F. D., Farias, M. I. T., Britto, C. T. F., Nóbrega, L. M. A., Nascimento-Junior, A. C., Alves, É. O., Pereira, R. M. C., Campos, V. C., Menezes, M., Martinelli-Júnior, C. E., Aguiar-Oliveira, M. H.
Format: Article
Language:English
Subjects:
Adult
Endocrinology
Female
Homozygote
Hormone Replacement Therapy - methods
Human Growth Hormone - deficiency
Human Growth Hormone - therapeutic use
Humans
Insulin-Like Growth Factor I - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Middle Aged
Original Articles
Receptors, Neuropeptide - genetics
Receptors, Pituitary Hormone-Regulating Hormone - genetics
Sex Hormone-Binding Globulin - metabolism
Thyroid Gland - anatomy & histology
Thyroid Gland - drug effects
Thyroid Gland - physiology
Thyrotropin - blood
Thyroxine - blood
Treatment Outcome
Triiodothyronine - blood
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Summary:Background: Conflicting data exist on the effects of GH replacement therapy (GHRT) on thyroid function and thyroid volume (TV) in GH-deficient (GHD) patients. Aim: The aim of this study was to assess the effects of GHRT on thyroid function and TV in adults with congenital lifetime isolated GHD (IGHD). Subjects and methods: We studied 20 GH-naïve adults with IGHD due to a homozygous mutation of the GHRH-receptor gene at baseline, after 6-month depot-GH replacement therapy (pGH), and 6-month washout (6mo). Total T 3 , free T 4 (FT 4 ), reverse T 3 (rT 3 ), TSH, IGF-I, SHBG, and TV were measured; body surface area-corrected TV (CTV) was calculated. Results: IGF-I and T 3 increased pGH. T 3 levels remained elevated at 6mo. GHRT did not significantly change FT 4 , rT 3 , TSH, and SHBG. TV and CTV increased pGH and remained elevated at 6mo. Conclusions: GHRT in IGHD adults caused an increase in serum T 3 levels and TV, suggesting an important role of the GH-IGF-I axis in thyroid function.
ISSN:0391-4097
1720-8386
DOI:10.3275/7608