Plasma ACTH Precursors in Cats with Pituitary‐Dependent Hyperadrenocorticism

Background Diagnosis of pituitary‐dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test. Hypothesis/Objective The determination of plasma ACTH precursor (POMC and pro‐ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the...

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Published in:Journal of veterinary internal medicine 2012-05, Vol.26 (3), p.575-581
Main Authors: Benchekroun, G., Fornel‐Thibaud, P., Dubord, M., Dossin, O., Fracassi, F., Rannou, B., Garnier, F., Maurey‐Guenec, C., Daminet, S., Rosenberg, D.
Format: Article
Language:English
Subjects:
Adrenocortical Hyperfunction - blood
Adrenocortical Hyperfunction - diagnosis
Adrenocortical Hyperfunction - urine
Adrenocortical Hyperfunction - veterinary
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
Animals
Cat Diseases - blood
Cat Diseases - diagnosis
Cat Diseases - urine
Cats
Cohort Studies
Corticotroph tumors
Cushing's disease
Feline
Female
Hydrocortisone - blood
Hydrocortisone - urine
Insulin-Like Growth Factor I - analysis
Male
Pituitary Gland - metabolism
Pro-Opiomelanocortin - blood
Prospective Studies
Pro‐adrenocorticotropin
Pro‐opiomelanocortin
Statistics, Nonparametric
Tomography, X-Ray Computed - veterinary
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Summary:Background Diagnosis of pituitary‐dependent hyperadrenocorticism (PDH) in cats is challenging because there is no specific diagnostic test. Hypothesis/Objective The determination of plasma ACTH precursor (POMC and pro‐ACTH) concentration might facilitate the diagnosis of PDH in cats. The aim of the study was to evaluate prospectively the plasma concentrations of ACTH precursors in a small cohort of cats with PDH and to estimate the value of this approach for diagnosis. Animals Four groups of cats were included: group 1 (cats with PDH), group 2 (cats with diabetes mellitus but not hyperadrenocorticism (HAC)), group 3 (cats with diabetes mellitus and confirmed acromegaly but not HAC), and group 4 (healthy cats). Methods PDH diagnosis was based on clinical data, low‐dose dexamethasone suppression test (LDDST), and adrenal and pituitary gland computed tomography (CT) scan. For groups 2, 3, and 4, hyperadrenocorticism was excluded by LDDST or urine cortisol:creatinine ratio (UCCR). An immunoluminometric assay was used to determine plasma concentrations of ACTH precursors in the 4 groups of cats. Results Group 1 contained 9 cats (enlarged pituitary gland in 7/9). Plasma ACTH precursor concentrations ranged from 1010 pmol/L with 8/9 concentrations ≥229 pmol/L. Groups 2, 3, and 4 included 13, 7, and 13 cats, respectively. Plasma ACTH precursor concentrations ranged from
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2012.00924.x