Simplification to monotherapy with lopinavir/ritonavir in adolescents with vertically acquired HIV-1 infection

In recent years, the use of boosted protease inhibitors monotherapy has become increasingly important, especially considering the advantages in terms of costs, tolerability, and simplification. Despite that, knowledge about the efficacy and safety of this approach in HIV-1-infected adolescents who h...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2012-02, Vol.24 (1), p.56-58
Main Authors: Schenone, Eva, Biagio, Antonio Di, Parisini, Andrea, Bruzzone, Bianca, Sticchi, Laura, Calzi, Anna, Nicco, Elena, Secondo, Giovanni, Viscoli, Claudio
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Female
HIV Infections - drug therapy
HIV Infections - transmission
HIV Infections - virology
HIV Protease Inhibitors - therapeutic use
HIV-1 - drug effects
HIV-1 - genetics
Human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious Disease Transmission, Vertical - prevention & control
Infectious diseases
Lopinavir - therapeutic use
lopinavir/ritonavir
Male
Medical sciences
Mother-to-child transmission
Perinatal transmission
Pharmacology. Drug treatments
Protease inhibitor monotherapy
Ritonavir - therapeutic use
RNA, Viral - genetics
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Young Adult
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Summary:In recent years, the use of boosted protease inhibitors monotherapy has become increasingly important, especially considering the advantages in terms of costs, tolerability, and simplification. Despite that, knowledge about the efficacy and safety of this approach in HIV-1-infected adolescents who have acquired HIV-1 infection through perinatal transmission is still limited. We report here our experience with two adolescents who have been successfully treated with lopinavir/ritonavir monotherapy.
ISSN:1120-009X
1973-9478
DOI:10.1179/1120009X12Z.00000000011