Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6

► HDAC6 expression correlates with mitochondrial metabolic activity. ► HDAC6 regulates mitochondrial metabolic activity in the cytoplasm. ► Both deacetylase and ubiquitin binding activities of HDAC6 are linked to it. ► HDAC6 does not affect the expression of nuclear-encoded mitochondrial enzymes. ►...

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Bibliographic Details
Published in:FEBS letters 2012-05, Vol.586 (9), p.1379-1383
Main Authors: Kamemura, Kazuo, Ogawa, Mitsutaka, Ohkubo, Saki, Ohtsuka, Yasuhiro, Shitara, Yu, Komiya, Tohru, Maeda, Satoko, Ito, Akihiro, Yoshida, Minoru
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cell Nucleus - enzymology
Citrate synthase
Down-Regulation
Gene Expression Regulation, Enzymologic
HDAC6
Histone Deacetylase 6
Histone Deacetylases - deficiency
Histone Deacetylases - metabolism
Homeostasis
Hsp90
Humans
MEF
Mice
Mitochondria
Mitochondria - enzymology
Mitochondria - metabolism
mouse embryonic fibroblast
Respiratory complex II
Succinate dehydrogenase
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Summary:► HDAC6 expression correlates with mitochondrial metabolic activity. ► HDAC6 regulates mitochondrial metabolic activity in the cytoplasm. ► Both deacetylase and ubiquitin binding activities of HDAC6 are linked to it. ► HDAC6 does not affect the expression of nuclear-encoded mitochondrial enzymes. ► Hsp90 partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial enzymes, including respiratory complex II and citrate synthase. HDAC6 deacetylase and ubiquitin-binding activities were both required for recovery of reduced mitochondrial metabolic activity due to the loss of HDAC6. Hsp90, a substrate of HDAC6, localizes to mitochondria and partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Our finding suggests that HDAC6 regulates mitochondrial metabolism and might serve as a cellular homeostasis surveillance factor.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2012.03.060