Radiographic Periodontal Bone Loss in Chronic Kidney Disease

Background: We examined the extent and severity of radiographic periodontal bone loss in patients with different stages of chronic kidney disease (CKD) and explored a potential dose–response relationship between bone loss and CKD‐related biomarkers. Methods: Panoramic radiographs were obtained from...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2012-05, Vol.83 (5), p.602-611
Main Authors: Messier, Marie‐Danielle, Emde, Karin, Stern, Leonard, Radhakrishnan, Jai, Vernocchi, Linda, Cheng, Bin, Angelopoulos, Christos, Papapanou, Panos N.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alveolar bone loss
Alveolar Bone Loss - blood
Alveolar Bone Loss - diagnostic imaging
Alveolar Bone Loss - etiology
Analysis of Variance
Biological and medical sciences
Biomarkers - blood
Blood Glucose - analysis
Chi-Square Distribution
chronic
chronic periodontitis
Dentistry
dialysis
Diseases of the osteoarticular system
epidemiology
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Glomerular Filtration Rate
Humans
inflammation
kidney failure
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - complications
Kidneys
Leukocyte Count
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Non tumoral diseases
Osteoporosis. Osteomalacia. Paget disease
Otorhinolaryngology. Stomatology
Radiography, Panoramic
Regression Analysis
Renal Dialysis - adverse effects
Serum Albumin - analysis
Urinary system involvement in other diseases. Miscellaneous
Young Adult
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Summary:Background: We examined the extent and severity of radiographic periodontal bone loss in patients with different stages of chronic kidney disease (CKD) and explored a potential dose–response relationship between bone loss and CKD‐related biomarkers. Methods: Panoramic radiographs were obtained from 129 CKD patients (78 males and 51 females; mean age: 63.5 years, range: 24 to 91 years), including 63 patients undergoing dialysis for an average of 3.3 years (range: 0.5 to 14 years). Glomerular filtration rate (GFR), dialysis dose, and levels of serum biomarkers were obtained through a hospital database. Interproximal bone loss was assessed as a percentage of root length. Results: Twenty‐nine participants were edentulous (23.8% of those on dialysis versus 21.2% of those with residual kidney function; χ2 test, P = 0.724). The extent of bone loss was higher among dialysis patients (analysis of variance [ANOVA], P = 0.007), but no clear dose–response association between CKD stage and extent was evident. GFR, dialysis dose, and levels of serum biomarkers did not differ between edentulous and dentate individuals, and only serum albumin was lower in patients with extensive bone loss (ANOVA, P = 0.030). After adjusting for dialysis status, the severity of bone loss was positively associated with glucose levels (multiple regression, P = 0.019) and white blood cell count (P = 0.032), whereas the number of teeth present was positively associated with plasma phosphorus (P = 0.008) and negatively with glucose levels (P = 0.011). Conclusion: Despite a higher extent of bone loss in dialysis patients, the lack of a dose–response association between bone loss and CKD stage or the levels of CKD‐related serum biomarkers underscores the complex relationship between the two conditions.
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2011.110306