JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton (STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for gene regulation that dramatically advanced our understanding of the action of hormones, interferons, colony-stimulating factor...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2012-04, Vol.36 (4), p.542-550
Main Authors: O'Shea, John J., Plenge, Robert
Format: Article
Language:English
Subjects:
Autoimmune Diseases - genetics
Autoimmune Diseases - metabolism
Autoimmune Diseases - therapy
Autoimmunity
Competition
Cytokines
Cytokines - immunology
Cytokines - metabolism
Gene expression
Gene Expression Regulation
Gene loci
Growth hormones
Humans
Immune system
Immunity, Innate
Interferons - immunology
Interferons - metabolism
Janus Kinases - antagonists & inhibitors
Janus Kinases - immunology
Janus Kinases - metabolism
Kinases
Rodents
Signal Transduction
STAT Transcription Factors - immunology
STAT Transcription Factors - metabolism
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Summary:The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton (STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for gene regulation that dramatically advanced our understanding of the action of hormones, interferons, colony-stimulating factors, and interleukins. As we learn more about the complexities of immune responses, new insights into the functions of this pathway continue to be revealed, aided by technology that permits genome-wide views. As we celebrate the 20th anniversary of the discovery of this paradigm in cell signaling, it is particularly edifying to see how this knowledge has rapidly been translated to human immune disease. Not only have genome-wide association studies demonstrated that this pathway is highly relevant to human autoimmunity, but targeting JAKs is now a reality in immune-mediated disease.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2012.03.014