Nucleosomes in gene regulation: Theoretical approaches

This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from the molecular-mechanistic and biol...

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Bibliographic Details
Published in:Molecular biology (New York) 2012-02, Vol.46 (1), p.1-10
Main Authors: Teif, V. B., Shkrabkou, A. V., Egorova, V. P., Krot, V. I.
Format: Article
Language:English
Subjects:
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Biophysics
Chromatin
Genomics
Human Genetics
Life Sciences
Molecular biology
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Summary:This work reviews current theoretical approaches of biophysics and bioinformatics for the description of nucleosome arrangements in chromatin and transcription factor binding to nucleosomal organized DNA. The role of nucleosomes in gene regulation is discussed from the molecular-mechanistic and biological points of view. In addition to classical problems in this field, actual questions of epigenetic regulation are discussed. The authors selected for discussion what seem to be the most interesting concepts and hypotheses. Mathematical approaches are described in a simplified language to attract attention to the most important directions of this field.
ISSN:0026-8933
1608-3245
DOI:10.1134/S002689331106015X