Tumor-platelet interaction in solid tumors

Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well‐documented clinical correlation be...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cancer 2012-06, Vol.130 (12), p.2747-2760
Main Authors: Buergy, Daniel, Wenz, Frederik, Groden, Christoph, Brockmann, Marc A.
Format: Article
Language:English
Subjects:
angiogenesis
Biological and medical sciences
Blood Platelets - pathology
Cancer
Hematologic and hematopoietic diseases
Humans
Medical prognosis
Medical research
Medical sciences
metastasis
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Neoplasm Metastasis
Neoplasms - blood
Neoplasms - blood supply
Neoplasms - pathology
Neovascularization, Pathologic
Platelet Count
Platelet diseases and coagulopathies
platelets
Survival
thrombocytosis
Thrombocytosis - pathology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well‐documented clinical correlation between platelet count and prognosis of solid tumors, the following questions arise: (i) Are the increased platelet counts the reason for shortened survival as platelet‐secreted cytokines might boost tumor growth and angiogenesis? (ii) Do platelets affect tumor metastasis thereby shortening survival time? or (iii) Are increased platelet counts simply an epiphenomenon of tumor growth with larger tumors resulting in higher platelet counts and shorter survival times? We address these three questions within our review of the current literature to provide a comprehensive overview of the current concepts in tumor–platelet interaction.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.27441