Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae

[Display omitted] ► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties. Propolis is derived from plant res...

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Bibliographic Details
Published in:Journal of invertebrate pathology 2012-05, Vol.110 (1), p.68-72
Main Authors: Mihai, Cristina Manuela, Mărghitaş, Liviu Al, Dezmirean, Daniel S., Chirilă, Flore, Moritz, Robin F.A., Schlüns, Helge
Format: Article
Language:English
Subjects:
American foul brood
American Foulbrood
Animal productions
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antibacterial properties
Apiculture
Apis mellifera
Bees - drug effects
Bees - microbiology
Biological and medical sciences
Flavonoids
Flavonoids - chemistry
Fundamental and applied biological sciences. Psychology
honey bee colonies
honey bees
Insecta
Invertebrates
larvae
Microbial Sensitivity Tests
Paenibacillus
Paenibacillus larvae
pathogens
Polyphenols
Propolis
Propolis - chemistry
Propolis - pharmacology
resins
Terrestrial animal productions
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Summary:[Display omitted] ► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties. Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.
ISSN:0022-2011
1096-0805
DOI:10.1016/j.jip.2012.02.009