Influence of botulinum toxin on rabbit jaw muscle activity and anatomy

Introduction: Muscles can adapt their fiber properties to accommodate to new conditions. We investigated the extent to which a decrease in muscle activation can cause an adaptation of fiber properties in synergistic and antagonistic jaw muscles. Methods: Three months after the injection of botulinum...

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Bibliographic Details
Published in:Muscle & nerve 2012-05, Vol.45 (5), p.684-691
Main Authors: Korfage, J.A.M., Wang, Jeffrey, Lie, S.H.J.T.J., Langenbach, Geerling E.J.
Format: Article
Language:English
Subjects:
Activation analysis
adaptation
Anatomy
Animals
Biological and medical sciences
Botulinum toxin
Botulinum toxin type A
Botulinum Toxins, Type A - pharmacology
digastric
Dinosaurs
Electric Stimulation
Electromyography
Fibers
Functional Laterality
Injection
Jaw
Male
Masseter Muscle - drug effects
mastication muscles
Medical sciences
Muscle
Muscle contraction
Muscles
Myosin
Neuromuscular Agents - pharmacology
Pharmacology. Drug treatments
rabbit
Rabbits
Statistics, Nonparametric
temporalis
Time Factors
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Summary:Introduction: Muscles can adapt their fiber properties to accommodate to new conditions. We investigated the extent to which a decrease in muscle activation can cause an adaptation of fiber properties in synergistic and antagonistic jaw muscles. Methods: Three months after the injection of botulinum toxin type A in one masseter (anterior or posterior) muscle changes in fiber type composition and fiber cross‐sectional areas in jaw muscles were studied at the microscopic level. Results: The injected masseter showed a steep increase in myosin type IIX fibers, whereas fast fibers decreased by about 50% in size. Depending on the injection site, both synergistic and antagonistic muscles showed a significant increase in the size of their fast IIA fibers, sometimes combined with an increased number of IIX fibers. Conclusion: Silencing the activity in the masseter not only causes changes in the fibers of the injected muscle but also leads to changes in other jaw muscles. Muscle Nerve, 2012
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.23229