Findings in the Pulmonary Vascular Bed in the Remote Phase After Kawasaki Disease

Kawasaki disease (KD) is a form of systemic vasculitis that causes chronic changes in arterial walls, including pulmonary arteries. The aim of this study was to test the hypothesis that pulmonary arterial wall properties and hemodynamics are abnormal after the resolution of KD. Pulmonary arterial in...

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Bibliographic Details
Published in:The American journal of cardiology 2012-04, Vol.109 (8), p.1219-1222
Main Authors: Sugimoto, Masaya, MD, PhD, Ishido, Hirotaka, MD, PhD, Seki, Mitsuru, MD, Masutani, Satoshi, MD, PhD, Tamai, Akiko, MD, Senzaki, Hideaki, MD, PhD
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biological and medical sciences
Blood Pressure - physiology
Cardiac Catheterization
Cardiography, Impedance
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Case-Control Studies
Child
Child, Preschool
Coronary Vessels - diagnostic imaging
Humans
Intubation
Medical sciences
Mucocutaneous Lymph Node Syndrome - physiopathology
Multivariate Analysis
Prospective Studies
Pulmonary arteries
Pulmonary Artery - physiopathology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Stroke Volume - physiology
Ultrasonography
Vascular Resistance - physiology
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Summary:Kawasaki disease (KD) is a form of systemic vasculitis that causes chronic changes in arterial walls, including pulmonary arteries. The aim of this study was to test the hypothesis that pulmonary arterial wall properties and hemodynamics are abnormal after the resolution of KD. Pulmonary arterial input impedance was measured during cardiac catheterization (4.8 ± 4.5 years after disease onset) in 47 consecutive patients (mean age 7.8 ± 5.7 years) with KD and coronary artery lesions (CALs) in the acute phase and 42 control patients (mean age 6.7 ± 4.6 years). Patients with KD were subdivided into 2 groups: 28 with persistent CALs and 19 with regressed CALs. There were no significant differences in characteristic impedance and peripheral vascular resistance between patients with KD and controls. Compared with controls, patients with persistent CALs had significantly lower pulmonary arterial compliance, suggesting increased wall stiffness of the peripheral pulmonary vascular bed (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.11.062