Gluconeogenesis and protein-induced satiety

Increased gluconeogenesis (GNG) has been suggested to contribute to protein-induced satiety via modulation of glucose homoeostasis. The objective was to determine GNG and appetite in healthy human subjects after a high-protein v. a normal-protein diet and to assess whether GNG contributes to protein...

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Bibliographic Details
Published in:British journal of nutrition 2012-02, Vol.107 (4), p.595-600
Main Authors: Veldhorst, Margriet A. B., Westerterp, Klaas R., Westerterp-Plantenga, Margriet S.
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid - blood
Adult
Appetite Depressants - administration & dosage
Appetite Regulation
Behaviour, Appetite and Obesity
Biological and medical sciences
Blood Glucose - analysis
Body Mass Index
Cross-Over Studies
Diet
Dietary Proteins - administration & dosage
Energy Metabolism
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Gluconeogenesis
Glucose
Glycogen - metabolism
Homeostasis
Humans
Male
Nutrition research
Proteins
Satiety Response
Single-Blind Method
Surveys and Questionnaires
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Young Adult
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Summary:Increased gluconeogenesis (GNG) has been suggested to contribute to protein-induced satiety via modulation of glucose homoeostasis. The objective was to determine GNG and appetite in healthy human subjects after a high-protein v. a normal-protein diet and to assess whether GNG contributes to protein-induced satiety. A total of twenty-two healthy subjects (ten men and twelve women: age 23 (sem 1) years, BMI 22·1 (sem 0·5) kg/m2) received an isoenergetic high-protein (30/0/70 % of energy from protein/carbohydrate/fat) or normal-protein diet (12/55/33 % of energy from protein/carbohydrate/fat) for 1·5 d in a randomised cross-over design. Appetite ratings were measured using visual analogue scales (VAS); endogenous glucose production and GNG were measured via infusion of [6,6-2H2]glucose and ingestion of 2H2O. Moreover, fasting glucose and β-hydroxybutyrate concentrations were measured. Glycogen stores were lowered at the start with a glycogen-lowering exercise test. During the high-protein compared with the normal-protein diet, GNG was increased and appetite was suppressed (GNG: 148 (sem 7) v. 133 (sem 6) g/24 h, P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114511003254