Oxaliplatin-induced acute thrombocytopenia

We describe a patient who experienced immediate onset severe thrombocytopenia as part of a hypersensitivity reaction to oxaliplatin, following substantial relatively uncomplicated previous exposure to the drug. We review other reports of acute hematological toxicity from oxaliplatin. We draw attenti...

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Bibliographic Details
Published in:Journal of oncology pharmacy practice 2011-12, Vol.17 (4), p.433-435
Main Authors: Mason, Jessica M, Rees, Gareth JG
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Blood platelets
Cancer
Case management
Chemotherapy
Humans
Male
Organoplatinum Compounds - adverse effects
Side effects
Thrombocytopenia - chemically induced
Thrombocytopenia - diagnosis
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Summary:We describe a patient who experienced immediate onset severe thrombocytopenia as part of a hypersensitivity reaction to oxaliplatin, following substantial relatively uncomplicated previous exposure to the drug. We review other reports of acute hematological toxicity from oxaliplatin. We draw attention to the important need for vigilance when patients develop unusual acute symptoms during or shortly after oxaliplatin infusion.
ISSN:1078-1552
1477-092X
DOI:10.1177/1078155210381287