Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk

Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism. The objective of this study was to determine whether soy isoflavone phase II metabolism differs between humans and r...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2011-11, Vol.94 (5), p.1284-1294
Main Authors: DR SETCHELL, Kenneth, BROWN, Nadine M, XUEHENG ZHAO, LINDLEY, Stephanie L, HEUBI, James E, KING, Eileen C, MESSINA, Mark J
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Biological and medical sciences
Breast - drug effects
Breast - metabolism
Breast cancer
Breast Neoplasms - chemically induced
Breast Neoplasms - prevention & control
Child, Preschool
Cross-Over Studies
Diet
Disease Models, Animal
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Genistein - blood
Humans
Infant
Isoflavones - administration & dosage
Isoflavones - blood
Male
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - metabolism
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - prevention & control
Metabolism
Mice
Mice, Inbred C57BL
Mice, Nude
Mice, Transgenic
Middle Aged
Premenopause - blood
Rats
Rats, Sprague-Dawley
Rodents
Soy Foods
Soy products
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin B
Young Adult
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Summary:Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences in isoflavone metabolism. The objective of this study was to determine whether soy isoflavone phase II metabolism differs between humans and rodents. Circulating total and unconjugated isoflavone concentrations were determined by mass spectrometry in plasma samples from 7 separate studies: 1) in Sprague-Dawley rats and in 3 strains of mice fed commercial soy-containing diets; 2) in Sprague-Dawley rats gavaged with genistein; 3) in healthy adults who consumed single servings of soy nuts, soy milk, and tempeh; 4) in healthy adults subchronically given soy milk; 5) in healthy women orally administered 50 mg genistein; 6) in healthy women orally administered 20 mg pure S-(-)equol; and 7) in 6-mo-old infants fed soy infant formula and later, at age 3 y, a soy germ isoflavone supplement. The proportion of unconjugated genistein in plasma from adults and infants who consumed different soy foods, pure genistein, or an isoflavone supplement was
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.111.019638