High laryngeal mask airway pressures resulting from nitrous oxide do not increase pharyngeal mucosal injury in dogs

During general anesthesia, nitrous oxide (N2O) diffuses rapidly into the air-filled laryngeal mask airway (LMA) cuff, increasing intracuff pressure. There is no clear correlation between LMA intracuff pressure and pressure on the pharynx. We have studied the effects of high LMA intracuff pressures s...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2001-09, Vol.48 (8), p.800-806
Main Authors: VILELA ABUD, Tania Mara, CERQUEIRA BRAZ, José Reinaldo, GARCIA MARTINS, Regina Helena, GREGORIO, Elisa Aparecida, SALDANHA, Joao Carlos
Format: Article
Language:English
Subjects:
Airway management
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - adverse effects
Animals
Biological and medical sciences
Dogs
Female
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Laryngeal Masks
Male
Medical research
Medical sciences
Microscopy, Electron, Scanning
Mucous membrane
Mucous Membrane - pathology
Mucous Membrane - ultrastructure
Nitrous Oxide - adverse effects
Pharynx - pathology
Pharynx - ultrastructure
Pressure
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Summary:During general anesthesia, nitrous oxide (N2O) diffuses rapidly into the air-filled laryngeal mask airway (LMA) cuff, increasing intracuff pressure. There is no clear correlation between LMA intracuff pressure and pressure on the pharynx. We have studied the effects of high LMA intracuff pressures secondary to N2O on the pharyngeal mucosa of dogs. Sixteen mongrel dogs were randomly allocated to two groups: G1 (intracuff volume, 30 mL; n=8) breathed a mixture of O2 (l L x min(-1)) and air (l L x min(-1)) and G2 (intracuff volume, 30 mL; n=8) a mixture of O2 (l L x min(-1)) and N2O (l L x min(-1)). Anesthesia was induced and maintained with pentobarbitone. LMA cuff pressure was measured at zero (control), 30, 60, 90 and 120 min after #4 LMA insertion. The dogs were sacrificed, and biopsy specimens from seven predetermined areas of the pharynx in contact with the LMA cuff were collected for light (LM) and scanning electron microscopic (SEM) examination by a blinded observer. LMA intracuff pressure decreased with time in G1 (P
ISSN:0832-610X
1496-8975
DOI:10.1007/BF03016698