Two oxovanadium complexes incorporating thiosemicarbazones: synthesis, characterization, and DNA-binding studies

An oxovanadium complex [VO(satsc)(phen)] (1) (satsc = salicylaldehyde thiosemicarbazone, phen = phenanthroline) and its derivative [VO(3,5-dibrsatsc)(phen)] (2) (3,5-dibrsatsc = 3,5-dibromosalicylaldehyde thiosemicarbazone) have been synthesized and characterized by elemental analysis, infrared, ele...

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Bibliographic Details
Published in:Journal of coordination chemistry 2011-04, Vol.64 (7), p.1229-1239
Main Authors: Lu, Jia-Zheng, Du, Yi-Fan, Guo, Hai-Wei, Jiang, Jing, Zeng, Xian-Dong, Zang, Lin-Quan
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Oxovanadium
Synthesis
Thermal denaturation
Thiosemicarbazone
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Summary:An oxovanadium complex [VO(satsc)(phen)] (1) (satsc = salicylaldehyde thiosemicarbazone, phen = phenanthroline) and its derivative [VO(3,5-dibrsatsc)(phen)] (2) (3,5-dibrsatsc = 3,5-dibromosalicylaldehyde thiosemicarbazone) have been synthesized and characterized by elemental analysis, infrared, electrospray-mass spectra, 1 H NMR, and magnetic susceptibility measurements. The DNA-binding behaviors of these complexes with calf-thymus DNA (CT-DNA) were investigated by UV-Vis absorption titration, fluorescence spectra, viscosity measurements, thermal denaturation, and circular dichroism. Both 1 and 2 bind to CT-DNA by intercalation and 1 exhibits much stronger binding affinity to CT-DNA than 2.
ISSN:0095-8972
1029-0389
DOI:10.1080/00958972.2011.565754