Accuracy of tumor size measurement in breast cancer using MRI is influenced by histological regression induced by neoadjuvant chemotherapy

The aim of this study was to evaluate whether regressive changes after neoadjuvant chemotherapy for breast cancer affect the accuracy of preoperative MRI measurements of tumor size. Thirty-one patients with breast cancer underwent MRI before and after neoadjuvant treatment. Besides pre- and post-con...

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Bibliographic Details
Published in:European radiology 2003-06, Vol.13 (6), p.1213-1223
Main Authors: Wasser, K, Sinn, H P, Fink, C, Klein, S K, Junkermann, H, Lüdemann, H P, Zuna, I, Delorme, S
Format: Article
Language:English
Subjects:
Accuracy
Antineoplastic Agents - therapeutic use
Breast - pathology
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer therapies
Chemotherapy
Contrast Media
Cyclophosphamide - therapeutic use
Epirubicin - therapeutic use
Female
Gadolinium DTPA
Histopathology
Humans
Magnetic Resonance Imaging - methods
Mammography
Middle Aged
Neoadjuvant Therapy
Paclitaxel - therapeutic use
Patients
Remission Induction
Surgery
Tumors
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Summary:The aim of this study was to evaluate whether regressive changes after neoadjuvant chemotherapy for breast cancer affect the accuracy of preoperative MRI measurements of tumor size. Thirty-one patients with breast cancer underwent MRI before and after neoadjuvant treatment. Besides pre- and post-contrast T1-weighted MRI, dynamic MRI with high temporal resolution (turbo-FLASH) was performed. Contrast enhancement in dynamic MRI was quantified using a pharmacokinetic two-compartment model, where two parameters, amplitude and k(ep), were calculated and color coded on transversal parameter maps. Considering the conventional MR images, tumor diameters were measured on the color maps and compared with histological tumor size. Histological regression was scored on a five-point scale regarding cytopathic effects, reactive changes, and tumor cell reduction. The correlation between tumor sizes measured by MRI and histopathology was 0.83 ( p
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-002-1730-6