Effects of Perinatal Exposure to PCBs on Neuropsychological Functions in the Rotterdam Cohort at 9 Years of Age

PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old...

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Bibliographic Details
Published in:Neuropsychology 2004-01, Vol.18 (1), p.185-193
Main Authors: Vreugdenhil, Hestien J. I, Mulder, Paul G. H, Emmen, Harry H, Weisglas-Kuperus, Nynke
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain
Breast Feeding
Child
Child clinical studies
Cohort Studies
Decision Making - drug effects
Environmental Effects
Environmental Pollutants
Female
Human
Humans
Intelligence
Male
Maternal Exposure
Medical sciences
Memory, Short-Term - drug effects
Milk, Human
Netherlands - epidemiology
Neural Development
Neuropsychological Tests
Neuropsychology
Neurotoxins
Organic mental disorders. Neuropsychology
Perinatal Period
Polychlorinated Biphenyls - toxicity
Pregnancy
Prenatal Exposure Delayed Effects
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - drug effects
Psychopathology. Psychiatry
Reaction Time
Regression Analysis
Statistics, Nonparametric
Verbal Learning - drug effects
Visual Perception - drug effects
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Summary:PCBs are known for their neurotoxic properties, especially on the developing brain. To increase insight into the neurotoxic effects of PCB exposure, the authors studied the effects of perinatal exposure to environmental levels of these compounds on different neuropsychological domains. In 9-year-old children of the Rotterdam PCB-dioxin cohort, higher prenatal PCB levels were associated with longer response times (RTs), more variation in RTs, and lower scores on the Tower of London (TOL; Shallice, 1982 ). A longer breast-feeding duration was associated with lower TOL scores and with better spatial organizational skills. There was some evidence of negative effects of lactational exposure to PCBs on scores on the TOL.
ISSN:0894-4105
1931-1559
DOI:10.1037/0894-4105.18.1.185