Predictive Importance of Vitamin D on Response to Neoadjuvant Chemotherapy in Turkish Patients with Locally Advanced Hormone Receptor Positive Breast Cancer

[LANGUAGE= "English"] Objectives: To investigate the relationship between the level of vitamin D with pathological response rates to neoad?juvant chemotherapy in breast cancer patients. Methods: The pathological responses of patients treated with neoadjuvant chemotherapy for locally advanc...

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Bibliographic Details
Published in:Eurasian journal of medical investigation 2021, Vol.5 (3), p.388
Main Author: Atci, Muhammed Mustafa
Format: Article
Language:eng ; tur
Subjects:
Breast cancer
Chemotherapy
Ethnicity
Multivariate analysis
Polymorphism
Response rates
Vitamin D
Vitamin deficiency
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Summary:[LANGUAGE= "English"] Objectives: To investigate the relationship between the level of vitamin D with pathological response rates to neoad?juvant chemotherapy in breast cancer patients. Methods: The pathological responses of patients treated with neoadjuvant chemotherapy for locally advanced breast cancer regarding Miller-Payne grading system were noted as ?90% and >90% response. Vitamin D deficiency was de?fined as 90 to neoadjuvant chemotherapy, respectively. In univariate analysis, tumor size, menopause status, and histologic grade were found to be statistically significant for pathological response. In multivariate analysis, progesteron receptor positivity, premenopause, and higher tumor diameter were associated with decreasing pathologic response. The level of vitamin D was not statistically significant on pathological response to neoadjuvant chemotherapy. Conclusion: The level of vitamin D level was not associated with pathologic response rates to neoadjuvant chemother?apy in Turkish population. This may be explained with vitamin D receptor polymorphism in different ethnicities which should be evaluated in future studies in terms of pathologic response to neoadjuvant chemotherapy.
ISSN:2602-3164
2602-3164
DOI:10.14744/ejmi.2021.99947