Long-term efficacy and safety of intravesical Bacillus Calmette-Guerin Moreau Polish substrain in the treatment of non-muscle invasive bladder cancer

MATERIAL AND METHODS This was a retrospective database analysis that used the register on BCG treatment of the Urology Department, University Hospital in Wroclaw. Patiënt data were collected in the regis-try since 1998, resulting in a prolonged follow-up pe-riod for the majority of patients. [...]a...

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Bibliographic Details
Published in:Central European journal of urology 2024-04, Vol.77 (2), p.196-202
Main Authors: Bursiewicz, Wiktor, Ztotkiewïcz, Monika, Krajewski, Wojciech, Tupikowski, Krzysztof, Kotodziej, Jan, Jünemann, Rolf, Mudra, Tobias, Witecy, Stefanie, Szydetko, Tomasz, Kotodziej, Anna
Format: Article
Language:English
Subjects:
Bladder cancer
Cancer therapies
Data analysis
Sensitivity analysis
Tumors
Urology
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Summary:MATERIAL AND METHODS This was a retrospective database analysis that used the register on BCG treatment of the Urology Department, University Hospital in Wroclaw. Patiënt data were collected in the regis-try since 1998, resulting in a prolonged follow-up pe-riod for the majority of patients. [...]a period of 48 months was assumed for the accumulation time in the power assessment. Sensitivity analysis for homogeneous follow-up times Primary effectiveness analysis was repeated for the per protocol (PP) subgroup PP60, including all patients with the theoretical chance of 60 months of follow-up. [...]possible differences between BCG strains in the therapy assignment to the patients and the affected event probability due to unbalanced event-free follow-up times were avoided. [...]matched pairs were used for analyses of differences between BCG strains, accounting for sample dependence.
ISSN:2080-4806
2080-4873
DOI:10.5173/ceju.2024.01