Graphene Field-Effect Transistor-Based Chemical Sensor With Functionalized Olfactory Receptors Immobilized in Solid Phase for Household Odor Detection

In this letter, we present a novel graphene field-effect transistor (gFET)-based chemical sensor that utilizes mammalian olfactory receptors (ORs) as selective gas-capturing materials for indoor odor detection. We have completed an electrochemical gating circuit that can directly measure gaseous tar...

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Bibliographic Details
Published in:IEEE sensors letters 2024-08, Vol.8 (8), p.1-4
Main Authors: Choi, Wan Seop, Jang, Yun Guk, Seo, Hye Kyoung, Kim, Oe Dong, Cho, Yong Ho, Jin, Won Hyeog, Choi, Eun Hwa, Lee, Sung Hee, Kim, Seong Hyok
Format: Article
Language:English
Subjects:
Air purification
Chemical and biological sensors
Chemical sensors
Ethane
Field effect transistors
Gas detectors
Gas sensors
Gases
Graphene
graphene field-effect transistor (gFET)
Household appliances
household odor
hydroxyl ethyl piperazine ethane sulfonic acid (HEPES)
IVA
Logic gates
Odors
Olfactory
olfactory receptor
Receptors
Semiconductor devices
Sensors
Solid phases
Spoilage
Sulfonic acid
Surface topography
Target detection
Toluene
Transistors
Trimethylamine
trimethylamine (TMA)
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Summary:In this letter, we present a novel graphene field-effect transistor (gFET)-based chemical sensor that utilizes mammalian olfactory receptors (ORs) as selective gas-capturing materials for indoor odor detection. We have completed an electrochemical gating circuit that can directly measure gaseous targets without using a liquid medium by functionalizing hydroxyl ethyl piperazine ethane sulfonic acid (HEPES) with ORs as the gas reaction layer and utilizing a graphene passivation layer as the FET gate. The gFET using HEPES-functionalized ORs was successfully fabricated through a standard CMOS-compatible manufacturing process. Our odor gas sensor can detect diluted trimethylamine (TMA) gas in air at concentrations of 100 ppb and can distinguish it from other gases, such as formaldehyde and toluene. We expect that it can be applied to household appliances to help indoor residents identify the cause of odors, such as fish spoilage and foot odor, by better understanding the context of odors. In fact, we anticipate that this odor gas sensor can be applied to refrigerators, indoor air purifiers, and other products.
ISSN:2475-1472
2475-1472
DOI:10.1109/LSENS.2024.3420404