Synthesis and stability of the [45Ti]Ti–DOTA complex: en route towards aza-macrocyclic 45Ti-based radiopharmaceuticals

We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid–liquid extraction method,...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-07, Vol.60 (56), p.7148-7151
Main Authors: Roy, Tamal, Pogorilyy, Eduard, Kumarananthan, Chubina P, Kvitastein, Unni A, Foscato, Marco, Törnroos, Karl W, Adamsen, Tom C H, Erwan Le Roux
Format: Article
Language:English
Subjects:
Liquid-liquid extraction
Radiochemistry
Radiolabelling
Stability
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Summary:We report the use of DOTA as a chelator for titanium. The resulting complex is fully characterised and in vitro stability studies reveal its high kinetic inertness against transmetallation and transchelation. The radiolabeling of DOTA with 45Ti, via a guaiacol-based liquid–liquid extraction method, leads to a high radiochemical conversion up to 98%.
ISSN:1359-7345
1364-548X
DOI:10.1039/d4cc01800a