Genetic association study for three single nucleotide polymorphisms related to type 2 diabetes in Egyptian population

Background Diabetes mellitus is a disease that may result from interaction between environmental factors and a strong genetic component. The current study is aimed at exploring three single nucleotide polymorphisms to identify the associated ones with type 2 diabetes in the Egyptian society. The stu...

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Bibliographic Details
Published in:Egyptian Journal of Medical Human Genetics 2024-07, Vol.25 (1), p.78-7
Main Authors: Zareef, Galena W, Moatmed, Ibrahim M, Shehata, Nourhan W, Saad, Mohamed N, Shaker, Olfat G
Format: Article
Language:English
Subjects:
Analysis
Chromosomes
CREB1
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes therapy
Diabetics
Eating disorders
Egyptian population
Environmental factors
Gene expression
Gene polymorphism
Genetic aspects
Genotype & phenotype
Genotyping
Glucose
GOAT
Goats
Haplotypes
Hyperglycemia
Insulin
MAFA
Population genetics
Population studies
Proteins
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Transcription factors
Type 2 diabetes
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Summary:Background Diabetes mellitus is a disease that may result from interaction between environmental factors and a strong genetic component. The current study is aimed at exploring three single nucleotide polymorphisms to identify the associated ones with type 2 diabetes in the Egyptian society. The studied single nucleotide polymorphisms (rs10096097 in GOAT, rs6740584 in CREB1, and rs62521874 in MAFA) were examined via genotyping cases (n = 98) and irrelevant healthy subjects (n = 82). Results Associations were checked using dominant, recessive, genotypic, allelic, and Cochran-Armitage trend models. By comparing diabetic patients with controls, rs6740584 was associated with type 2 diabetes by employing all used models except the recessive model. Rs10096097 was connected with type 2 diabetes using the genotypic association, Cochran-Armitage trend test, and recessive model and not any other model. Rs62521874 was not linked with type 2 diabetes in all models. Moreover, haplotype association for rs10096097 and rs62521874 was conducted as these two single nucleotide polymorphisms were located on the same chromosome. The haplotype pattern rs10096097:G-rs62521874:A was identified as a biomarker for type 2 diabetes susceptibility in the Egyptian community. Conclusions The GOAT and CREB1 polymorphisms showed susceptibility to type 2 diabetes. Moreover, MAFA had no role in the disease except through the haplotype with GOAT polymorphism.
ISSN:1110-8630
2090-2441
DOI:10.1186/s43042-024-00546-x