Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology

Models of inflammation, oxidative stress, hyperoxia and hypoxia have demonstrated that magnesium sulfate (MgS[O.sub.4]), a commonly used drug in obstetrics, has neuroprotective potential. In the present study, the effects of MgS[O.sub.4] treatment on inflammation, oxidative stress and fetal brain hi...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2024-07, Vol.28 (1), Article 286
Main Authors: Ozdemir, Cagri, Isik, Berrin, Koca, Gulce, Inan, Mehmet Arda
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia in obstetrics
Apoptosis
Automation
Autophagy
Blood pressure
Brain research
Care and treatment
Complications and side effects
Development and progression
Drug dosages
FDA approval
Fetal brain
Fetuses
Health aspects
Histopathology
Inflammation
Ketamine
Laboratory animals
Magnesium sulfate
Methods
Neuroprotective agents
Neurotoxicity
Obstetrics
Oxidative stress
Pregnancy
Pregnancy, Complications of
Sevoflurane
Surgery
Testing
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Summary:Models of inflammation, oxidative stress, hyperoxia and hypoxia have demonstrated that magnesium sulfate (MgS[O.sub.4]), a commonly used drug in obstetrics, has neuroprotective potential. In the present study, the effects of MgS[O.sub.4] treatment on inflammation, oxidative stress and fetal brain histopathology were evaluated in an experimental rat model following sevoflurane (Sv) exposure during the mid-gestational period. Rats were randomly divided into groups: C (control; no injections or anesthesia), Sv (exposure to 2.5% Sv for 2 h), MgS[O.sub.4] (administered 270 mg/kg MgS[O.sub.4] intraperitoneally) and Sv + MgS[O.sub.4] (Sv administered 30 min after MgS[O.sub.4] injection). Inflammatory and oxidative stress markers were measured in the serum and neurotoxicity was investigated histopathologically in fetal brain tissue. Short-term mid-gestational exposure to a 1.1 minimum alveolar concentration of Sv did not significantly increase the levels of any of the measured biochemical markers, except for TNF-[alpha]. Histopathological evaluations demonstrated no findings suggestive of pathological apoptosis, neuroinflammation or oxidative stress-induced cell damage. MgS[O.sub.4] injection prior to anesthesia caused no significant differences in biochemical or histopathological marker levels compared to the C and Sv groups. The present study indicated that short-term exposure to Sv could potentially be considered a harmless external stimulus to the fetal brain. Key words: sevoflurane, magnesium sulfate, fetal brain, neuroapoptosis, inflammation, oxidative stress
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2024.12574