In Vivo Stimulation of Therapeutic Antigen‐Specific T Cells in an Artificial Lymph Node Matrix (Adv. Mater. 23/2024)

Artificial Lymph Node In article number 2310043, Hai‐Quan Mao, Jonathan P. Schneck, and co‐workers report an artificial lymph node (aLN) biomatrix composed of a hydrogel conjugated with T cell stimulating signals. Following subcutaneous injection, this aLN biomatrix develops into a complex immune ni...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2024-06, Vol.36 (23), p.n/a
Main Authors: Livingston, Natalie K., Hickey, John W., Sim, Hajin, Salathe, Sebastian F., Choy, Joseph, Kong, Jiayuan, Silver, Aliyah B., Stelzel, Jessica L., Omotoso, Mary O., Li, Shuyi, Chaisawangwong, Worarat, Roy, Sayantika, Ariail, Emily C., Lanis, Mara R., Pradeep, Pratibha, Bieler, Joan Glick, Witte, Savannah Est, Leonard, Elissa, Doloff, Joshua C., Spangler, Jamie B., Mao, Hai‐Quan, Schneck, Jonathan P.
Format: Article
Language:English
Subjects:
adoptive T cell therapy
Antigens
artificial lymph node
cancer
hydrogel
Hydrogels
Immune system
immunotherapy
in vivo activation
Lymphatic system
Lymphocytes
T cell stimulation
Tumors
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Summary:Artificial Lymph Node In article number 2310043, Hai‐Quan Mao, Jonathan P. Schneck, and co‐workers report an artificial lymph node (aLN) biomatrix composed of a hydrogel conjugated with T cell stimulating signals. Following subcutaneous injection, this aLN biomatrix develops into a complex immune niche in vivo. Naïve, adoptively transferred T cells are stimulated within the aLN in an antigen‐specific manner through direct interaction with the matrix. The cover art depicts a novel aLN hydrogel biomatrix which when injected subcutaneously, is capable of simulating adoptively transferred naïve T cells and recruiting an array of endogenous immune cells. Upon entering the porous biomatrix, naïve T cells (green) bind to the antigen‐specific stimulating signals conjugated to the hydrogel matrix and are activated (yellow) and interact with the recruited cells in the dynamic immune microenvironment, which facilitate the expansion and differentiation into effector and memory T‐cells (orange). The activated T cells then emigrate and travel to the tumor where they can directly kill the tumor cells and lead to increased survival of animals with established tumors.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202470177