Recent advances in the biosynthesis, bioavailability, toxicology, pharmacology, and controlled release of citrus neohesperidin

Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential applications ranging from food ingredients to therapeutics. The purpose of this manuscript is to provide a comprehensive overvi...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2024-06, Vol.64 (15), p.5073-5092
Main Authors: Akhter, Saima, Arman, Md. Saiful Islam, Tayab, Mohammed Abu, Islam, Mohammad Nazmul, Xiao, Jianbo
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents - pharmacokinetics
Anti-Infective Agents - pharmacology
Anti-Inflammatory Agents - pharmacokinetics
Anti-Inflammatory Agents - pharmacology
Bioavailability
Biocompatibility
Biological Availability
Biosynthesis
Citrus - chemistry
Citrus fruits
Clinical trials
Controlled release
Delayed-Action Preparations
Diabetes mellitus
Fruit - chemistry
Hesperidin
Hesperidin - analogs & derivatives
Hesperidin - pharmacokinetics
Hesperidin - pharmacology
Humans
Hypoglycemic Agents - pharmacokinetics
Hypoglycemic Agents - pharmacology
In vivo methods and tests
Inflammatory diseases
Literature reviews
neohesperidin
Neohesperidin dihydrochalcone
Neuroprotection
Neuroprotective Agents - pharmacokinetics
Neuroprotective Agents - pharmacology
Osteoporosis
Pharmacokinetics
pharmacological activity
Pharmacology
Toxicity
Toxicology
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Summary:Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential applications ranging from food ingredients to therapeutics. The purpose of this manuscript is to provide a comprehensive overview of the chemical, biosynthesis, and pharmacokinetics profiles of neohesperidin, as well as the therapeutic effects and mechanisms of neohesperidin against potential diseases. This literature review covers a wide range of pharmacological responses elicited by Neohesperidin, including neuroprotective, anti-inflammatory, antidiabetic, antimicrobial, and anticancer activities, with a focus on the mechanisms of those pharmacological responses. Additionally, the mechanistic pathways underlying the compound's osteoporosis, antiulcer, cardioprotective, and hepatoprotective effects have been outlined. This review includes detailed illustrations of the biosynthesis, biopharmacokinetics, toxicology, and controlled release of neohesperidine. Neohesperidin demonstrated a broad range of therapeutic and biological activities in the treatment of a variety of complex disorders, including neurodegenerative, hepato-cardiac, cancer, diabetes, obesity, infectious, allergic, and inflammatory diseases. Neohesperidin is a promising therapeutic candidate for the management of various etiologically complex diseases. However, further in vivo and in vitro studies on mechanistic potential are required before clinical trials to confirm the safety, bioavailability, and toxicity profiles of neohesperidin.
ISSN:1040-8398
1549-7852
1549-7852
DOI:10.1080/10408398.2022.2149466