Advanced Sequencing Techniques to Map RNA Methylation

RNA methylation is a crucial epigenetic modification widely present in RNA molecules, and has been demonstrated to play significant roles in diverse biological processes. Advances in detection and sequencing technologies have facilitated the identification of RNA modification‐related regulatory prot...

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Bibliographic Details
Published in:Israel journal of chemistry 2024-03, Vol.64 (3-4), p.n/a
Main Authors: Song, Ge‐Ge, Fan, Xiu, Gao, Chun‐Chun, Zhao, Yong‐Liang, Yang, Yun‐Gui
Format: Article
Language:English
Subjects:
Biological activity
biological functions
distribution characteristics
Gene sequencing
Methylation
Proteins
regulatory proteins
RNA methylation
sequencing techniques
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Summary:RNA methylation is a crucial epigenetic modification widely present in RNA molecules, and has been demonstrated to play significant roles in diverse biological processes. Advances in detection and sequencing technologies have facilitated the identification of RNA modification‐related regulatory proteins and their corresponding biological functions. In this paper, we provide a brief overview of several RNA methylation, including N6‐methyladenosine(m6A), 5‐methylcytidine(m5C), N1‐methyladenosine(m1A), N7‐methylguanosine(m7G) and N6, 2’‐O‐dimethyladenosine(m6Am), about their regulatory proteins, distribution patterns and biological functions, and mainly outline the advantages and limitations of the representative sequencing techniques. Finally, we discuss the technological challenges and future perspectives in RNA transcriptomic field.
ISSN:0021-2148
1869-5868
DOI:10.1002/ijch.202400003