Cyanine-based nanoparticles for near-infrared triggered photothermal therapy against S. aureus

Noninvasive antibacterial therapies, such as photothermal therapy (PTT), have shown great promise to treat pathogens due to low toxicity and low drug resistance. Photothermal transducing agents (PTAs) play a pivotal role to make PTT a spatiotemporally controllable and effective technique. In this st...

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Bibliographic Details
Published in:New journal of chemistry 2024-03, Vol.48 (13), p.5674-5680
Main Authors: Song, Shuang, Yang, Na, He, Di, Li, Ying, Akhtar, Mahmood Hassan, Liu, Chang, Li, Xiwen, Shen, Xiande, Yu, Cong
Format: Article
Language:English
Subjects:
Biocompatibility
Controllability
Cyanine dyes
Galactose
Nanoparticles
Nanostructured materials
Polyethylene glycol
Wound healing
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Summary:Noninvasive antibacterial therapies, such as photothermal therapy (PTT), have shown great promise to treat pathogens due to low toxicity and low drug resistance. Photothermal transducing agents (PTAs) play a pivotal role to make PTT a spatiotemporally controllable and effective technique. In this study, we designed and prepared a novel nanostructured material by using a cyanine dye (Flav7) as a PTA for the treatment of S. aureus infection. 1,2-Distearoyl- sn -glycero-3-phosphoethanolamine polyethylene glycol galactose (DSPE-PEGG) was used to fabricate the nanoparticles (Flav7@DSPE-PEGG NPs) by encapsulating Flav7, and the Flav7@DSPE-PEGG NPs exhibited excellent water-dispersibility, photothermal stability, and biocompatibility. The results show that the constructed Flav7@DSPE-PEGG NPs retained good targeting capability and achieved a remarkable 99.9% eradication rate against S. aureus under 808 nm laser irradiation, and efficiently promoted infected wound healing by PTT.
ISSN:1144-0546
1369-9261
DOI:10.1039/D3NJ04226J