Design of SAHA-Loaded PLGA Nanoparticles Aimed for Use in Breast Cancer Combination Therapy

This work is devoted to development of a method for synthesis of vorinostat-loaded nanoparticles based on a copolymer of lactic and glycolic acids. The technology of synthesis of polymeric particles was optimized with the help of the Box–Behnken design. The nanoparticles synthesized by using the opt...

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Bibliographic Details
Published in:Physics of atomic nuclei 2023-12, Vol.86 (11), p.2490-2495
Main Authors: Gulyaev, I. A., Sokol, M. B., Klimenko, M. A., Mollaeva, M. R., Yabbarov, N. G., Chirkina, M. V., Nikolskaya, E. D.
Format: Article
Language:English
Subjects:
Chemical synthesis
Copolymers
Glycolic acid
High performance liquid chromatography
Medical Physics and Biophysics
Nanoparticles
Particle and Nuclear Physics
Physics
Physics and Astronomy
Polydispersity
Synthesis
Zeta potential
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Summary:This work is devoted to development of a method for synthesis of vorinostat-loaded nanoparticles based on a copolymer of lactic and glycolic acids. The technology of synthesis of polymeric particles was optimized with the help of the Box–Behnken design. The nanoparticles synthesized by using the optimized technology had a spherical shape, which was confirmed by transmission electron microscopy. The average diameter of the nanoparticles was 196 nm, the polydispersity index was 0.089, and the zeta potential was –22.3 mV. Drug loading in the nanoparticles was 0.91 wt %; the analysis was performed by high-performance liquid chromatography.
ISSN:1063-7788
1562-692X
DOI:10.1134/S1063778823110170