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Design, Synthesis, Antimicrobial Evaluation, and Molecular Docking Studies of Carbamoyl Phosphonates
A novel class of carbamoyl phosphonates derivatives of dimethyl, ethyl, and aryl phosphonates were prepared by one-pot synthesis through treatment with 4-methyl benzene sulfonyl isocyanates. The synthesized carbamoyl phosphonates were studied their antimicrobial activity and docking studies. The att...
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Published in: | Russian journal of organic chemistry 2023-12, Vol.59 (Suppl 1), p.S67-S73 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | A novel class of carbamoyl phosphonates derivatives of dimethyl, ethyl, and aryl phosphonates were prepared by one-pot synthesis through treatment with 4-methyl benzene sulfonyl isocyanates. The synthesized carbamoyl phosphonates were studied their antimicrobial activity and docking studies. The attained results displayed that, most of the products have significant antibacterial activity against both Gram-positive (
Staphylococcus aureus
,
Bacillus subtilis
) and Gram-negative bacteria (
Pseudomonas aeruginosa
,
Escherichia
coli
). The compound
3d
shown good antifungal activity against
Aspergillus niger
,
Trichoderma viride
. In addition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) was also calculated. Although molecular docking studies provide the bonding interaction between the product and DNA Gyrase binding pocket it shows the stability of the drug. The compound
3d
(Diphenyl (tosylcarbamoyl) phosphonate) is found to be a potential antimicrobial agent against
Pseudomonas aeruginosa
and
Trichoderma viride
and
3d
also showed hydrophobic interaction with 3LPX. |
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ISSN: | 1070-4280 1608-3393 |
DOI: | 10.1134/S1070428023130067 |