Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism

High-Z ion doped hydroxyapatite, including zirconium doped hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with doped ion could assist ion doped hydroxyapatite accumulates in cancer cell compared to non doped hydroxyap...

Full description

Saved in:
Bibliographic Details
Main Authors: Febrian, Muhamad Basit, Kurniawan, Ahmad, Fikri, Ahsanal, Mahendra, Isa, Wibawa, Teguh Hafiz Ambar, Sulaiman, Sulaiman, Juliyanto, Sumandi, Setiadi, Yanuar, Rattyananda, Badra Sanditya, Dewanti, Maria Rosa, Putra, Amal Rezka
Format: Conference Proceeding
Language:English
Subjects:
Binding energy
Docking
Hydroxyapatite
Kinases
Lung cancer
Proteins
Receptors
Scandium
Therapy
Tyrosine
Zirconium
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 1
container_start_page
container_title
container_volume 2967
creator Febrian, Muhamad Basit
Kurniawan, Ahmad
Fikri, Ahsanal
Mahendra, Isa
Wibawa, Teguh Hafiz Ambar
Sulaiman, Sulaiman
Juliyanto, Sumandi
Setiadi, Yanuar
Rattyananda, Badra Sanditya
Dewanti, Maria Rosa
Putra, Amal Rezka
description High-Z ion doped hydroxyapatite, including zirconium doped hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with doped ion could assist ion doped hydroxyapatite accumulates in cancer cell compared to non doped hydroxyapatite. However the mechanism of ion doped hydroxyapatite internalization in cancer cell is currentle unknown. In this study, internalization of scandium-46 (46Sc) labeled zirconium doped hydroxyapatite (HApZr) and 46Sc non doped hydroxyapatite (HAp) in A549 lung cancer cell line was carried out to understand the effect of zirconium doping into HAp. Docking study was carried out to compared HApZr and HAp binding energy to several receptor proteins related to internalization including receptor tyrosine kinase of ERBB2 and PI3K/AKT protein kinase B. HApZr was internalized higher in lung cancer compared to HAp. Docking study revealed that binding energy of HApZr with ERBB2 and PI3K protein was lower compared to HAp. ERBB2 and PI3K protein are overexpressed in cancer cell thus could be a key for cancer survival pathway. Lower binding energy of HApZr stimulates higher uptake of HApZr in cancer cell compared to HAp as obtained in internalization study. These findings have important implications for further development of HApZr or other ion doped hydroxyapatite as potential agent for x-ray induced therapy of cancer.
doi_str_mv 10.1063/5.0193439
format conference_proceeding
fullrecord <record><control><sourceid>proquest_scita</sourceid><recordid>TN_cdi_proquest_journals_2926859144</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2926859144</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1689-7e65c923ef1191ab26606085a31847fc4b3753bf2d2d55566a9c8f2c9d3e49b43</originalsourceid><addsrcrecordid>eNotkE1LxDAYhIMouK4e_AcBb0LXfLc5yuLHwoIXBW8lTVI3S5rUpgW7B3-7rbunlxlmHngHgFuMVhgJ-sBXCEvKqDwDC8w5znKBxTlYICRZRhj9vARXKe0RIjLPiwX43YTedkF5d1C9iwHGGiatgnFDkzEBvaqstwYeXKdjmExoYjvp3Wi6-DOqdmr1FroA_RC-4NTUtoPaeg8nyOwn552OMPWDGWe66xNsrN6p4FJzDS5q5ZO9Od0l-Hh-el-_Ztu3l836cZu1WBQyy63gWhJqa4wlVhURAglUcEVxwfJas4rmnFY1McRwzoVQUhc10dJQy2TF6BLcHbltF78Hm_pyH4f57VQSSUTBJWZz6v6YStr1_3OUbeca1Y0lRuW8b8nL0770D5W5bdE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>conference_proceeding</recordtype><pqid>2926859144</pqid></control><display><type>conference_proceeding</type><title>Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism</title><source>American Institute of Physics:Jisc Collections:Transitional Journals Agreement 2021-23 (Reading list)</source><creator>Febrian, Muhamad Basit ; Kurniawan, Ahmad ; Fikri, Ahsanal ; Mahendra, Isa ; Wibawa, Teguh Hafiz Ambar ; Sulaiman, Sulaiman ; Juliyanto, Sumandi ; Setiadi, Yanuar ; Rattyananda, Badra Sanditya ; Dewanti, Maria Rosa ; Putra, Amal Rezka</creator><contributor>Wisnubroto, Djarot Sulistio ; Syaifudin, Mukh ; Antariksawan, Anhar Riza ; Santoso, Muhayatun ; Yusuf, Muhammad ; Mulyani, Emy</contributor><creatorcontrib>Febrian, Muhamad Basit ; Kurniawan, Ahmad ; Fikri, Ahsanal ; Mahendra, Isa ; Wibawa, Teguh Hafiz Ambar ; Sulaiman, Sulaiman ; Juliyanto, Sumandi ; Setiadi, Yanuar ; Rattyananda, Badra Sanditya ; Dewanti, Maria Rosa ; Putra, Amal Rezka ; Wisnubroto, Djarot Sulistio ; Syaifudin, Mukh ; Antariksawan, Anhar Riza ; Santoso, Muhayatun ; Yusuf, Muhammad ; Mulyani, Emy</creatorcontrib><description>High-Z ion doped hydroxyapatite, including zirconium doped hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with doped ion could assist ion doped hydroxyapatite accumulates in cancer cell compared to non doped hydroxyapatite. However the mechanism of ion doped hydroxyapatite internalization in cancer cell is currentle unknown. In this study, internalization of scandium-46 (46Sc) labeled zirconium doped hydroxyapatite (HApZr) and 46Sc non doped hydroxyapatite (HAp) in A549 lung cancer cell line was carried out to understand the effect of zirconium doping into HAp. Docking study was carried out to compared HApZr and HAp binding energy to several receptor proteins related to internalization including receptor tyrosine kinase of ERBB2 and PI3K/AKT protein kinase B. HApZr was internalized higher in lung cancer compared to HAp. Docking study revealed that binding energy of HApZr with ERBB2 and PI3K protein was lower compared to HAp. ERBB2 and PI3K protein are overexpressed in cancer cell thus could be a key for cancer survival pathway. Lower binding energy of HApZr stimulates higher uptake of HApZr in cancer cell compared to HAp as obtained in internalization study. These findings have important implications for further development of HApZr or other ion doped hydroxyapatite as potential agent for x-ray induced therapy of cancer.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/5.0193439</identifier><identifier>CODEN: APCPCS</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Binding energy ; Docking ; Hydroxyapatite ; Kinases ; Lung cancer ; Proteins ; Receptors ; Scandium ; Therapy ; Tyrosine ; Zirconium</subject><ispartof>AIP Conference Proceedings, 2024, Vol.2967 (1)</ispartof><rights>Author(s)</rights><rights>2024 Author(s). Published by AIP Publishing.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>310,311,315,786,790,795,796,23958,23959,25170,27957,27958</link.rule.ids></links><search><contributor>Wisnubroto, Djarot Sulistio</contributor><contributor>Syaifudin, Mukh</contributor><contributor>Antariksawan, Anhar Riza</contributor><contributor>Santoso, Muhayatun</contributor><contributor>Yusuf, Muhammad</contributor><contributor>Mulyani, Emy</contributor><creatorcontrib>Febrian, Muhamad Basit</creatorcontrib><creatorcontrib>Kurniawan, Ahmad</creatorcontrib><creatorcontrib>Fikri, Ahsanal</creatorcontrib><creatorcontrib>Mahendra, Isa</creatorcontrib><creatorcontrib>Wibawa, Teguh Hafiz Ambar</creatorcontrib><creatorcontrib>Sulaiman, Sulaiman</creatorcontrib><creatorcontrib>Juliyanto, Sumandi</creatorcontrib><creatorcontrib>Setiadi, Yanuar</creatorcontrib><creatorcontrib>Rattyananda, Badra Sanditya</creatorcontrib><creatorcontrib>Dewanti, Maria Rosa</creatorcontrib><creatorcontrib>Putra, Amal Rezka</creatorcontrib><title>Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism</title><title>AIP Conference Proceedings</title><description>High-Z ion doped hydroxyapatite, including zirconium doped hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with doped ion could assist ion doped hydroxyapatite accumulates in cancer cell compared to non doped hydroxyapatite. However the mechanism of ion doped hydroxyapatite internalization in cancer cell is currentle unknown. In this study, internalization of scandium-46 (46Sc) labeled zirconium doped hydroxyapatite (HApZr) and 46Sc non doped hydroxyapatite (HAp) in A549 lung cancer cell line was carried out to understand the effect of zirconium doping into HAp. Docking study was carried out to compared HApZr and HAp binding energy to several receptor proteins related to internalization including receptor tyrosine kinase of ERBB2 and PI3K/AKT protein kinase B. HApZr was internalized higher in lung cancer compared to HAp. Docking study revealed that binding energy of HApZr with ERBB2 and PI3K protein was lower compared to HAp. ERBB2 and PI3K protein are overexpressed in cancer cell thus could be a key for cancer survival pathway. Lower binding energy of HApZr stimulates higher uptake of HApZr in cancer cell compared to HAp as obtained in internalization study. These findings have important implications for further development of HApZr or other ion doped hydroxyapatite as potential agent for x-ray induced therapy of cancer.</description><subject>Binding energy</subject><subject>Docking</subject><subject>Hydroxyapatite</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Proteins</subject><subject>Receptors</subject><subject>Scandium</subject><subject>Therapy</subject><subject>Tyrosine</subject><subject>Zirconium</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2024</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNotkE1LxDAYhIMouK4e_AcBb0LXfLc5yuLHwoIXBW8lTVI3S5rUpgW7B3-7rbunlxlmHngHgFuMVhgJ-sBXCEvKqDwDC8w5znKBxTlYICRZRhj9vARXKe0RIjLPiwX43YTedkF5d1C9iwHGGiatgnFDkzEBvaqstwYeXKdjmExoYjvp3Wi6-DOqdmr1FroA_RC-4NTUtoPaeg8nyOwn552OMPWDGWe66xNsrN6p4FJzDS5q5ZO9Od0l-Hh-el-_Ztu3l836cZu1WBQyy63gWhJqa4wlVhURAglUcEVxwfJas4rmnFY1McRwzoVQUhc10dJQy2TF6BLcHbltF78Hm_pyH4f57VQSSUTBJWZz6v6YStr1_3OUbeca1Y0lRuW8b8nL0770D5W5bdE</recordid><startdate>20240215</startdate><enddate>20240215</enddate><creator>Febrian, Muhamad Basit</creator><creator>Kurniawan, Ahmad</creator><creator>Fikri, Ahsanal</creator><creator>Mahendra, Isa</creator><creator>Wibawa, Teguh Hafiz Ambar</creator><creator>Sulaiman, Sulaiman</creator><creator>Juliyanto, Sumandi</creator><creator>Setiadi, Yanuar</creator><creator>Rattyananda, Badra Sanditya</creator><creator>Dewanti, Maria Rosa</creator><creator>Putra, Amal Rezka</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope></search><sort><creationdate>20240215</creationdate><title>Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism</title><author>Febrian, Muhamad Basit ; Kurniawan, Ahmad ; Fikri, Ahsanal ; Mahendra, Isa ; Wibawa, Teguh Hafiz Ambar ; Sulaiman, Sulaiman ; Juliyanto, Sumandi ; Setiadi, Yanuar ; Rattyananda, Badra Sanditya ; Dewanti, Maria Rosa ; Putra, Amal Rezka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1689-7e65c923ef1191ab26606085a31847fc4b3753bf2d2d55566a9c8f2c9d3e49b43</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Binding energy</topic><topic>Docking</topic><topic>Hydroxyapatite</topic><topic>Kinases</topic><topic>Lung cancer</topic><topic>Proteins</topic><topic>Receptors</topic><topic>Scandium</topic><topic>Therapy</topic><topic>Tyrosine</topic><topic>Zirconium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Febrian, Muhamad Basit</creatorcontrib><creatorcontrib>Kurniawan, Ahmad</creatorcontrib><creatorcontrib>Fikri, Ahsanal</creatorcontrib><creatorcontrib>Mahendra, Isa</creatorcontrib><creatorcontrib>Wibawa, Teguh Hafiz Ambar</creatorcontrib><creatorcontrib>Sulaiman, Sulaiman</creatorcontrib><creatorcontrib>Juliyanto, Sumandi</creatorcontrib><creatorcontrib>Setiadi, Yanuar</creatorcontrib><creatorcontrib>Rattyananda, Badra Sanditya</creatorcontrib><creatorcontrib>Dewanti, Maria Rosa</creatorcontrib><creatorcontrib>Putra, Amal Rezka</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Febrian, Muhamad Basit</au><au>Kurniawan, Ahmad</au><au>Fikri, Ahsanal</au><au>Mahendra, Isa</au><au>Wibawa, Teguh Hafiz Ambar</au><au>Sulaiman, Sulaiman</au><au>Juliyanto, Sumandi</au><au>Setiadi, Yanuar</au><au>Rattyananda, Badra Sanditya</au><au>Dewanti, Maria Rosa</au><au>Putra, Amal Rezka</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism</atitle><btitle>AIP Conference Proceedings</btitle><date>2024-02-15</date><risdate>2024</risdate><volume>2967</volume><issue>1</issue><issn>0094-243X</issn><eissn>1551-7616</eissn><coden>APCPCS</coden><abstract>High-Z ion doped hydroxyapatite, including zirconium doped hydroxyapatite has prospects as drug candidates for x-ray induced dynamic therapy (XDT) in cancer therapy. Its nanosized combined with doped ion could assist ion doped hydroxyapatite accumulates in cancer cell compared to non doped hydroxyapatite. However the mechanism of ion doped hydroxyapatite internalization in cancer cell is currentle unknown. In this study, internalization of scandium-46 (46Sc) labeled zirconium doped hydroxyapatite (HApZr) and 46Sc non doped hydroxyapatite (HAp) in A549 lung cancer cell line was carried out to understand the effect of zirconium doping into HAp. Docking study was carried out to compared HApZr and HAp binding energy to several receptor proteins related to internalization including receptor tyrosine kinase of ERBB2 and PI3K/AKT protein kinase B. HApZr was internalized higher in lung cancer compared to HAp. Docking study revealed that binding energy of HApZr with ERBB2 and PI3K protein was lower compared to HAp. ERBB2 and PI3K protein are overexpressed in cancer cell thus could be a key for cancer survival pathway. Lower binding energy of HApZr stimulates higher uptake of HApZr in cancer cell compared to HAp as obtained in internalization study. These findings have important implications for further development of HApZr or other ion doped hydroxyapatite as potential agent for x-ray induced therapy of cancer.</abstract><cop>Melville</cop><pub>American Institute of Physics</pub><doi>10.1063/5.0193439</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0094-243X
ispartof AIP Conference Proceedings, 2024, Vol.2967 (1)
issn 0094-243X
1551-7616
language eng
recordid cdi_proquest_journals_2926859144
source American Institute of Physics:Jisc Collections:Transitional Journals Agreement 2021-23 (Reading list)
subjects Binding energy
Docking
Hydroxyapatite
Kinases
Lung cancer
Proteins
Receptors
Scandium
Therapy
Tyrosine
Zirconium
title Internalization of scandium-46 labeled zirconium doped hydroxyapatite in lung cancer cell and in silico study of its mechanism
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T22%3A29%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_scita&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=proceeding&rft.atitle=Internalization%20of%20scandium-46%20labeled%20zirconium%20doped%20hydroxyapatite%20in%20lung%20cancer%20cell%20and%20in%20silico%20study%20of%20its%20mechanism&rft.btitle=AIP%20Conference%20Proceedings&rft.au=Febrian,%20Muhamad%20Basit&rft.date=2024-02-15&rft.volume=2967&rft.issue=1&rft.issn=0094-243X&rft.eissn=1551-7616&rft.coden=APCPCS&rft_id=info:doi/10.1063/5.0193439&rft_dat=%3Cproquest_scita%3E2926859144%3C/proquest_scita%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p1689-7e65c923ef1191ab26606085a31847fc4b3753bf2d2d55566a9c8f2c9d3e49b43%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2926859144&rft_id=info:pmid/&rfr_iscdi=true