Physicochemical characterization and biological effect of 3D-nanofibrous alumina scaffolds produced by solution blow spinning

The objective of this study was to conduct a physicochemical characterization and in vivo assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this...

Full description

Saved in:
Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2024-02, Vol.26 (2), p.26, Article 26
Main Authors: dos Reis, Danyella Carolyna Soares, Linhares, Camila Rodrigues Borges, da Costa Farias, Rosiane Maria, Gomes, Deborah Santos, de Araújo Neves, Gelmires, Batista, Jonas Dantas, Dechichi, Paula, de Souza Castro Filice, Leticia, Menezes, Romualdo Rodrigues, Rocha, Flaviana Soares
Format: Article
Language:English
Subjects:
Alumina
Aluminum
Aluminum nitrate
Aluminum oxide
Biological activity
Biological effects
Bone growth
Characterization and Evaluation of Materials
Chemistry and Materials Science
Cotton
Distilled water
Ethanol
In vivo methods and tests
Inorganic Chemistry
Lasers
Materials Science
Nanofibers
Nanotechnology
Optical Devices
Optics
Photonics
Physical Chemistry
Physicochemical analysis
Polyvinylpyrrolidone
Regeneration
Regeneration (physiology)
Research Paper
Roasting
Scaffolds
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The objective of this study was to conduct a physicochemical characterization and in vivo assessment of the bioactivity of amorphous 3D-nanofibrous alumina scaffolds, manufactured using the Solution Blow Spinning (SBS) technique, for the purpose of bone regeneration. The nanofibers utilized in this research were derived from a solution containing aluminum nitrate, polyvinylpyrrolidone (PVP), ethanol, and distilled water, and were subsequently spun using SBS. The resulting scaffolds underwent calcination at 500 °C. Physicochemical analysis of the scaffolds was carried out, and their biological effects were evaluated in the femurs of Wistar rats. The scaffolds exhibited an amorphous structure consisting of nanofibers with an average diameter of 290 nm. They presented a cotton-wool-like 3D configuration after calcination process. Histomorphometric analysis revealed a significantly higher degree of bone neoformation within the alumina groups compared to the control group during both experimental periods (p 
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-024-05934-3