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Synthesis of derivatives of 6-aryl-2,2′-bipyridine complexes with PtII as potential antitumor agents
New Pt II complexes of aryl- and diaryl-2,2′-bipyridines were prepared using the Kröhnke method for the further synthesis of pyridine derivatives. Signal assignment in the 1 H and 13 C NMR spectra was performed for the 1D and 2D NMR spectral data. The primary screening evaluation of the antitumor ac...
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Published in: | Russian chemical bulletin 2023-12, Vol.72 (12), p.2848-2859 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | New Pt
II
complexes of aryl- and diaryl-2,2′-bipyridines were prepared using the Kröhnke method for the further synthesis of pyridine derivatives. Signal assignment in the
1
H and
13
C NMR spectra was performed for the 1D and 2D NMR spectral data. The primary screening evaluation of the antitumor activity of the synthesized compounds on cultured human cells in vitro showed high biological significance of selected samples. The cell death under the action of the studied compounds proceeds
via
apoptosis type as shown by fluorescent dyeing and polymerase chain reaction in the real time. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-023-4094-5 |