Synthesis and anti-inflammatory activity of 4-aryl-2-[(3-cyanothiophen-2-yl)amino]-4-oxobut-2-enoates

4-Aryl-4-oxo-2-(thiophen-2-ylamino)but-2-enoates bearing a cyano functional group at the thiophene ring were synthesized by the reaction of the corresponding substituted 3-(thiophen-2-ylamino)-3 H -furan-2-ones with primary alcohols. Evaluation of biological activity and acute toxicity of the synthe...

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Bibliographic Details
Published in:Russian chemical bulletin 2023-12, Vol.72 (12), p.3005-3012
Main Authors: Sharavyeva, Yu. O., Gorbunova, I. A., Makhmudov, R. R., Shipilovskikh, D. A., Silaichev, P. S., Shipilovskikh, S. A.
Format: Article
Language:English
Subjects:
Alcohols
Aromatic compounds
Biological activity
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Esters
Full Articles
Functional groups
Inorganic Chemistry
Organic Chemistry
Toxicity
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Summary:4-Aryl-4-oxo-2-(thiophen-2-ylamino)but-2-enoates bearing a cyano functional group at the thiophene ring were synthesized by the reaction of the corresponding substituted 3-(thiophen-2-ylamino)-3 H -furan-2-ones with primary alcohols. Evaluation of biological activity and acute toxicity of the synthesized esters revealed their pronounced anti-inflammatory effect and low toxicity.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-023-4112-7