Management Considerations for Lipid Disorders During Pregnancy

Purpose of review Dyslipidemias including familial hypercholesterolemia and elevated lipoprotein (a) are not uncommon in young women who may desire pregnancy. In all women, abnormal lipid metabolism has been linked to adverse outcomes during pregnancy, including hypertensive disease of pregnancy, ge...

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Bibliographic Details
Published in:Current treatment options in cardiovascular medicine 2021-07, Vol.23 (7), p.50, Article 50
Main Authors: Tummala, Lakshmi S., Agrawal, Akanksha, Lundberg, Gina
Format: Article
Language:English
Subjects:
Cardiology
Cardiovascular disease
Lipids
Medicine
Medicine & Public Health
Premature birth
Reproductive Health and Cardiovascular Disease (G Sharma
Section Editor
Topical Collection on Reproductive Health and Cardiovascular Disease
Womens health
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Summary:Purpose of review Dyslipidemias including familial hypercholesterolemia and elevated lipoprotein (a) are not uncommon in young women who may desire pregnancy. In all women, abnormal lipid metabolism has been linked to adverse outcomes during pregnancy, including hypertensive disease of pregnancy, gestational diabetes mellitus, and preterm birth. Optimal management of dyslipidemias in pregnant women remains undefined, as statins are contraindicated in this group. Recent findings Recent literature questions this traditional avoidance of statins, however, as well as explores their potential benefit in pre-eclampsia specifically. Summary In this review, the arsenal of nutrition, bile acid resins, omega-3 fatty acids, and low-density lipoprotein cholesterol apheresis is explored, as are newer therapies like mipomersen and proprotein convertase subtilisin/kexin type 9 inhibitors, for the management of dyslipidemias during pregnancy.
ISSN:1092-8464
1534-3189
DOI:10.1007/s11936-021-00926-1