Stain Etched Nanostructured Porous Silicon: The Role of Morphology on Antibacterial Drug Loading and Release

In this work, nanostructured porous silicon (pSi) prepared by a metal-assisted stain etched route is investigated for its ability to act as a carrier for sustained delivery of the antibacterial drug triclosan. The morphology, analyzed by transmission electron microscopy, reveals a rather different m...

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Bibliographic Details
Published in:SILICON 2016-10, Vol.8 (4), p.525-531
Main Authors: Wang, Mengjia, Hartman, Philip S., Loni, Armando, Canham, Leigh T., Coffer, Jeffery L.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Environmental Chemistry
Inorganic Chemistry
Lasers
Materials Science
Morphology
Nanostructure
Optical Devices
Optics
Original Paper
Photonics
Polymer Sciences
Porous silicon
Spectrophotometry
Thermogravimetric analysis
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Summary:In this work, nanostructured porous silicon (pSi) prepared by a metal-assisted stain etched route is investigated for its ability to act as a carrier for sustained delivery of the antibacterial drug triclosan. The morphology, analyzed by transmission electron microscopy, reveals a rather different microstructure than traditional anodized porous silicon; as a consequence, such morphology manifests a different loaded drug crystallinity, triclosan release behavior, and associated antibacterial activity versus Staphococcus aureus relative to high porosity anodized porous silicon. In addition to electron microscopies and antibacterial disk diffusion assays, a combination of x-ray diffraction, thermogravimetric analyses, and UV/Vis spectrophotometric analysis of triclosan release are employed to carry out the above investigations.
ISSN:1876-990X
1876-9918
DOI:10.1007/s12633-015-9397-1