Effects of Mo-Rubbing abdomen manipulation on glucose metabolism and inflammatory factors in rats with type 2 diabetes mellitus

Objective To observe the effect of Mo-Rubbing abdomen manipulation on glucose metabolism and inflammatory factors in rats with type 2 diabetes mellitus (T2DM). Methods Sixty Sprague-Dawley rats were randomly divided into a normal group ( n =10) and a group for modeling ( n =50) using the random numb...

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Bibliographic Details
Published in:Journal of acupuncture and tuina science 2022-10, Vol.20 (5), p.354-362
Main Authors: Xie, Zhouyu, Xu, Jingsong, Kong, Xintian, Wu, Yunchuan
Format: Article
Language:English
Subjects:
Abdomen
Acupuncture
Basic Study
Diabetes
Glucose
Medicine
Medicine & Public Health
Metabolism
Morphology
Tumor necrosis factor-TNF
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Summary:Objective To observe the effect of Mo-Rubbing abdomen manipulation on glucose metabolism and inflammatory factors in rats with type 2 diabetes mellitus (T2DM). Methods Sixty Sprague-Dawley rats were randomly divided into a normal group ( n =10) and a group for modeling ( n =50) using the random number table method. Rats in the group for modeling were induced to form T2DM models by a high-sugar and high-fat diet combined with intraperitoneal injection of streptozotocin. Thirty successfully modeled rats were randomly divided into a model group, a Mo-Rubbing abdomen group, and a metformin group, with 10 rats in each group. Rats in the normal group and the model group received no intervention, those in the Mo-Rubbing abdomen group received Mo-Rubbing abdomen manipulation, and those in the metformin group received metformin by gavage. After 8-week intervention, fasting insulin (FINS), fasting plasma glucose (FPG), homeostasis model assessment for insulin resistance (HOMA-IR) and area under the curve at the oral glucose tolerance test (AUC-OGTT), as well as serum inflammatory factors interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α were detected, and the morphological changes of the pancreas were also observed. Results After the 8-week intervention, the levels of FINS, FPG, HOMA-IR, and AUC-OGTT of rats in the Mo-Rubbing abdomen group were significantly lower than those in the model group ( P
ISSN:1672-3597
1993-0399
DOI:10.1007/s11726-022-1336-2