An Optoelectronic Spectral Sensor for Monitoring the Elimination of Uremic Markers with Low and Middle Molecular Weight during Hemodialysis Therapy

An optoelectronic spectral system was developed for monitoring the elimination of uremia markers of low and middle molecular weight during hemodialysis therapy by measuring UV absorption at 285 and 365 nm. The elimination kinetics of AGE products were analyzed using a two-pool model in comparison wi...

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Bibliographic Details
Published in:Biomedical engineering 2022-05, Vol.56 (1), p.18-23
Main Authors: Zemchenkov, G. A., Konoplev, G. A., Korsakov, V., Kuznetsov, A. I., Roshchina, N. V., Stepanova, O. S., Frorip, A.
Format: Article
Language:English
Subjects:
Absorption
Adequacy
Age
Biomaterials
Biomedical and Life Sciences
Biomedicine
Chronic kidney failure
Dialysate
Dialyzers
Engineering
Hemodialysis
Kinetics
Light emitting diodes
Metabolism
Molecular weight
Monitoring
Optoelectronic devices
Patients
Prognosis
Sensors
Toxins
Uremia
Uric acid
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Summary:An optoelectronic spectral system was developed for monitoring the elimination of uremia markers of low and middle molecular weight during hemodialysis therapy by measuring UV absorption at 285 and 365 nm. The elimination kinetics of AGE products were analyzed using a two-pool model in comparison with the conventional markers for dialysis adequacy. These studies showed that monitoring of optical absorption at 365 nm could be used as an alternative method for assessing hemodialysis adequacy.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-022-10158-7