Slow motions in nondeuterated proteins: Concerted chemical shift modulations of backbone nuclei

A simple method designed to measure autorelaxation rates of double- and zero-quantum coherences DQC/ZQC{C′N} involving a carbonyl C′ and the neighboring amide N nucleus in protein backbones provides valuable insight into slow motions in spite of interference both from the attached amide proton HN an...

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Bibliographic Details
Published in:Applied magnetic resonance 2005-06, Vol.29 (2), p.251-259
Main Authors: Wist, J., Perazzolo, C., Bodenhausen, G.
Format: Article
Language:English
Subjects:
Carbonyls
Chemical equilibrium
Proteins
Protons
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Summary:A simple method designed to measure autorelaxation rates of double- and zero-quantum coherences DQC/ZQC{C′N} involving a carbonyl C′ and the neighboring amide N nucleus in protein backbones provides valuable insight into slow motions in spite of interference both from the attached amide proton HN and from remote protons such as Hα in nondeuterated proteins. The method has been applied to human ubiquitin.
ISSN:0937-9347
1613-7507
DOI:10.1007/BF03167012