Synthesis and characterization of biocompatible poly(maleic acid-co-citric acid) microparticles as a smart carrier for thiamine

Novel biocompatible homo and co-polymeric microparticles were synthesized from maleic acid (MA) and citric acid (CA) for uptake/release thiamine as a model drug. Surfactant-free self-emulsion polymerization technique was accomplished to synthesize the microparticles in a single step. The antimicrobi...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2021-11, Vol.78 (11), p.6305-6320
Main Authors: Alpaslan, Duygu, Erşen Dudu, Tuba, Kubilay, Şenol, Aktaş, Nahit
Format: Article
Language:English
Subjects:
Acids
Adenosine
Antimicrobial agents
Antioxidants
Biocompatibility
Biomedical materials
Carboxylic acids
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Citric acid
Complex Fluids and Microfluidics
Controlled release
Drug delivery systems
Emulsion polymerization
Fourier transforms
Infrared analysis
Infrared spectroscopy
Investigations
Maleic acid
Microparticles
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Semiempirical equations
Soft and Granular Matter
Spectrum analysis
Surfactants
Synthesis
Thermal decomposition
Thermogravimetric analysis
Thiamine
Vitamin B
Zeta potential
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Summary:Novel biocompatible homo and co-polymeric microparticles were synthesized from maleic acid (MA) and citric acid (CA) for uptake/release thiamine as a model drug. Surfactant-free self-emulsion polymerization technique was accomplished to synthesize the microparticles in a single step. The antimicrobial, antioxidant properties of those microparticles and their thiamine uptake/release capacities were investigated. Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyzer (TGA), particle-size/zeta-potential (Zeta/DLS) and scanning electron microscopy (SEM) instruments were utilized for the characterizations of microparticles. FTIR revealed the existence of bonding interaction between the carboxylic acid groups of CA and MA. TGA results represented that thermal decomposition of microparticles was gradually continuing up to 1000 °C. The hydrodynamic diameters of poly (CA), poly (MA), poly (CA-co-MA) microparticles were found to be in the range of 681 nm, 1273 nm, 1604 nm, respectively. The zeta potential of those microparticles was in the range of  − 5.69 mV,  − 16.90 mV and  − 7.73 mV, respectively. The studies demonstrated that all microparticles have superior properties to absorb and release thiamine compared with similar candidates. Furthermore, controlled release behavior of thiamine was examined using zero sequence, first-order, Higuchi and Korsmeyer-Peppas models in PBS solutions at pH 7.4. Thiamine release from all microparticles exhibits a very high correlation with the Korsmeyer–Peppas semiempirical model and could be interpreted by the superposition of both Fickian diffusion and non-Fickian diffusion based on Peppas’ semiempirical equation. Superior capacities of microparticles, synthesized in one step without formation of toxic by-products, to absorb and release thiamine, aside from their biocompatible, antioxidant and antimicrobial properties make them valuable materials in nanotechnology and biomedical applications.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-020-03405-y