Tuning the Morphology of Au/ZnO Nanocomposite Using Pulsed Laser Ablation for Anticancer Applications

Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in de...

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Bibliographic Details
Published in:Arabian journal for science and engineering (2011) 2024, Vol.49 (1), p.1063-1074
Main Authors: Alheshibri, Muidh, Elsayed, Khaled A., Khan, Firdos Alam, Haladu, Shamsuddeen A., Ercan, Filiz, Çevik, Emre, Drmosh, Q. A., Kayed, T. S., Almessiere, M. A.
Format: Article
Language:English
Subjects:
Deionization
Engineering
Gold
Humanities and Social Sciences
Laser ablation
multidisciplinary
Nanocomposites
Nanomaterials
Pulsed lasers
Raman spectroscopy
Research Article-Physics
Science
Zinc oxide
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Summary:Developing a nanosized platform for annihilating cancer cells is highly promising and desirable in the field of nanomedicine especially when an eco-friendly synthesis protocol such as laser ablation is employed. Herein, pulsed laser ablation technique was used to fabricate Au/ZnO nanocomposite in deionized water. The prepared nanostructures were examined using HRTEM, SEM, EDX, XRD, UV–Vis, and Raman spectroscopy. An in vitro cytotoxicity evaluation of the prepared Au/ZnO nanocomposite on human colorectal carcinoma HCT116 and cervical cancer HeLa cells reveals the strong inhibitory action of the nanomaterials on the cancer cells. The influence of the nanocomposites on healthy HEK-293 cell line used as a control was minimal. The outcomes of this work mark the merits of laser ablation in the fabrication of highly pure nanomaterials with good efficacy against cancer cells.
ISSN:2193-567X
1319-8025
2191-4281
DOI:10.1007/s13369-023-08061-8