Baclofen and 4-Phenylpyrrolidone Derivative GIZH-290 Attenuates Compulsive-Like Behavior in Mice

Obsessive-compulsive disorder (OCD) is a mental disease characterized by the obsessions which cause marked distress or anxiety and/or compulsions intended to alleviate this distress. The results of experimental and clinical studies suggest a possible role of GABA B receptors in the pathogenesis of O...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology 2023-11, Vol.59 (6), p.2346-2354
Main Authors: Kudryashov, N. V., Volkova, A. V., Kozin, Ya. S., Shimshirt, A. A., Naplekova, P. L., Korolev, A. O., Voronina, T. A.
Format: Article
Language:English
Subjects:
8-Hydroxy-2-(di-n-propylamino)tetralin
Animal models
Animal Physiology
Baclofen
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Experimental Papers
Life Sciences
Mental disorders
Obsessive compulsive disorder
Spontaneous alternation
γ-Aminobutyric acid B receptors
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Summary:Obsessive-compulsive disorder (OCD) is a mental disease characterized by the obsessions which cause marked distress or anxiety and/or compulsions intended to alleviate this distress. The results of experimental and clinical studies suggest a possible role of GABA B receptors in the pathogenesis of OCD, making it relevant to study the effect of ligands of these receptors on the behavior of rodents. Objectives : Studying the effects of GIZH-290 and baclofen in animal models of OCD. Methods . The effects of GIZH-290 (0.01, 0.1, 1 mg/kg, i.p.) and baclofen (0.1, 1, and 5 mg/kg, i.p.) were studied in the marble burying test and the rotarod test, as well as in the 8-OH-DPAT-induced decrease in spontaneous alternation in mice. Results . Baclofen and GIZH-290 attenuated compulsive-like behavior in mice by reducing the number of buried marbles in the marble burying test at all tested doses. However, the effect of baclofen at a dose of 5 mg/kg was accompanied by a disruption of the animals’ motor coordination in the rotarod test. At the same time, neither baclofen nor GIZH-290 attenuated 8-OH-DPAT-induced (2 mg/kg, i.p.) decrease in spontaneous alternation behavior in mice. On the contrary, baclofen at a dose of 1 mg/kg exacerbated this disruption. Conclusion . Baclofen and GIZH-290 have anticompulsive activity in the marble burying test, but not in the 8-OH-DPAT-induced decrease in spontaneous alternation behavior in mice.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093023060352